Physical Activity and High-Sensitivity C-Reactive Protein in Pregnancy: Does It Matter During Leisure or Work?

Details

• Personal Author:
  Birukov A ; Chen L ; Holtermann A ; Li J ; Liu X ; Lu R ; Tsai MY ; Weir NL ; Zhang C
• Description:
  Introduction: Physical activity (PA), regardless of domain, is recommended for pregnant individuals in clinical guidelines, but limited evidence is available for work-related PA. This study aimed to examine the associations of occupational (OPA) and leisure-time PA (LTPA) with plasma high-sensitivity C-reactive protein (hs-CRP), a risk marker for adverse pregnancy outcomes, among pregnant individuals. Methods: This longitudinal study included 257 workers in the fetal growth cohort. OPA/LTPA and hs-CRP were measured in each trimester. OPA/LTPA was divided into high and low groups by the median level. Multivariable linear regressions were applied to estimate the adjusted geometric mean differences of hs-CRP (mg·L-1) comparing high versus low OPA/LTPA in each trimester and the changes in OPA/LTPA over pregnancy. Results: OPA was positively associated with hs-CRP (high: 5.14 vs low: 3.59; P value: 0.001) in the first trimester, particularly for standing/walking or walking fast, regardless of carrying things. LTPA was negatively associated with hs-CRP in the second (high: 3.93 vs low: 5.08; 0.02) and third trimesters (high: 3.30 vs low: 4.40; 0.046). Compared with the low OPA + high LTPA group, hs-CRP was higher in both the high OPA + high LTPA and high OPA + low LTPA groups in the first trimester, and in the high OPA + low LTPA group only in the third trimester. The change in OPA during pregnancy was positively associated with hs-CRP, whereas the change in LTPA was negatively associated with hs-CRP from the second to the third trimester. Conclusions: In pregnant individuals, LTPA was negatively associated with hs-CRP, whereas OPA was positively associated with hs-CRP. More research on OPA's health impact among pregnant individuals is needed, and guidelines may consider the potential unfavorable influence of OPA on pregnant individuals. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Occupational Health Pregnancy Safety
• Keywords:
  Activity Levels Author Keywords: Pregnancy Chronic Inflammation Cohort Studies Exercise High-sensitivity C-reactive Protein Leisure-time Physical Activity Longitudinal Study Maternal Health Occupational Physical Activity Physical Exercise

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• ISSN:
  0195-9131
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Massachusetts ; Minnesota ; Missouri ; OSHA Region 1 ; OSHA Region 5 ; OSHA Region 7 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  110-117
• Volume:
  56
• Issue:
  1
• NIOSHTIC Number:
  nn:20069471
• Citation:
  Med Sci Sports Exerc 2024 Jan; 56(1):110-117
• Contact Point Address:
  Cuilin Zhang, M.D., M.P.H., Ph.D., Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Singapore, Singapore, 119228
• Email:
  obgzc@nus.edu.sg
• Federal Fiscal Year:
  2024
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Medicine and Science in Sports and Exercise
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:55035623c41d4aada88b2a121c882f3f84371dbe0672299eb3e8eb484cd1a855fc5c82dfc6cd49dd558dfcd147977ab804342ee3b4e3533b08cd27726d6b04a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/207908/cdc_207908_DS1.pdf
• File Type:
  [PDF - 308.85 KB ]