Association of Urinary Biomarkers of Smoking-Related Toxicants with Lung Cancer Incidence in Smokers: The Multiethnic Cohort Study

Details

• Personal Author:
  Cigan, Shannon S. ; Hecht, Stephen S. ; Le Marchand, Loic ; Murphy, Sharon E. ; Park, Sungship L. ; Stepanov, Irina ; Stram, Daniel O.
• Description:
  Background: While cigarette smoking is the leading cause of lung cancer, the majority of smokers do not develop the disease over their lifetime. The inter-individual differences in risk among smokers may in part be due to variations in exposure to smoking-related toxicants. Methods: Using data from a subcohort of 2,309 current smokers at the time of urine collection from the Multiethnic Cohort Study, we prospectively evaluated the association of ten urinary biomarkers of smoking-related toxicants [total nicotine equivalents (TNE), a ratio of total trans-3'-hydroxycotinine (3-HCOT)/cotinine (a phenotypic measure of CYP2A6 enzymatic activity), 4-(methylnitrosamino)-1-3-(pyridyl)-1-butanol (NNAL), S-phenylmercapturic acid (SPMA), 3-hydroxypropyl mercapturic acid (3-HPMA), phenanthrene tetraol (PheT), 3-hydroxyphenanthrene (PheOH), the ratio of PheT/PheOH, cadmium (Cd), and (Z)-7-(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenyl]hept-5-enoic acid (8-iso-PGF2a)] with lung cancer risk (n = 140 incident lung cancer cases over an average of 13.4 years of follow-up). Lung cancer risk was estimated using Cox proportional hazards models. Results: After adjusting for decade of birth, sex, race/ethnicity, body mass index, self-reported pack-years, creatinine, and urinary TNE (a biomarker of internal smoking dose), a one SD increase in log total 3-HCOT/cotinine (HR, 1.33; 95% CI, 1.06-1.66), 3-HPMA (HR, 1.41; 95% CI, 1.07-1.85), and Cd (HR, 1.45; 95% CI, 1.18-1.79) were each associated with increased lung cancer risk. Conclusions: Our study demonstrates that urinary total 3-HCOT/cotinine, 3-HPMA, and Cd are positively associated with lung cancer risk. These findings warrant replication and consideration as potential biomarkers for smoking-related lung cancer risk. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cadmium Cohort Studies Epidemiology Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Smokers Urine

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• Keywords:
  Biological Monitoring Cancer Rates Cohort Studies Lung Cancer Smoking Urine Chemistry
• ISSN:
  1055-9965
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Hawaii ; Minnesota ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  9 pdf pages
• Volume:
  32
• NIOSHTIC Number:
  nn:20067057
• Citation:
  Cancer Epidemiol Biomark Prev 2023 Mar; 32(3):306-314
• Contact Point Address:
  Sungshim L. Park, University of Hawaii Cancer Center, Epidemiology Program, 701 Ilalo Street, Honolulu, HI 96813
• Email:
  lpark@cc.hawaii.edu
• CAS Registry Number:
  3-(Hydroxypropyl)mercapturic acid (CAS RN 23127-40-4) ; Cadmium (CAS RN 7440-43-9) ; Cotinine (CAS RN 486-56-6)
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f0f3a5e596dcbad02c8ea849a9405943f68435eb0bfe8035ac77682e9bd1c5ccd038985e4b96565ed3e745b9cbd19e826630639a01f5764baead6913c37197a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/230744/cdc_230744_DS1.pdf
• File Type:
  [PDF - 267.37 KB ]