Mechanistic and Therapeutic Approaches to Occupational Exposure-Associated Allergic and Non-Allergic Asthmatic Disease

Details

• Personal Author:
  Poole, Jill A. ; Schwab, Aaron D.
• Description:
  Purpose of Review: Occupational lung disease, including asthma, is a significant cause of disability worldwide. The dose, exposure frequency, and nature of the causal agent influence the inflammatory pathomechanisms that inform asthma disease phenotype and progression. While surveillance, systems engineering, and exposure mitigation strategies are essential preventative considerations, no targeted medical therapies are currently available to ameliorate lung injury post-exposure and prevent chronic airway disease development. Recent Findings: This article reviews contemporary understanding of allergic and non-allergic occupational asthma mechanisms. In addition, we discuss the available therapeutic options, patient-specific susceptibility and prevention measures, and recent scientific advances in post-exposure treatment conception. Summary: The course of occupational lung disease that follows exposure is informed by individual predisposition, immunobiologic response, agent identity, overall environmental risk, and preventative workplace practices. When protective strategies fail, knowledge of underlying disease mechanisms is necessary to inform targeted therapy development to lessen occupational asthma disease severity and occurrence. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Environmental Exposure Hypersensitivity Immune System Lung Diseases Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Allergic Reactions Allergy Author Keywords: Airway Hyperresponsiveness Environmental Exposure Immune Reaction Immunotherapy Inflammation Lung Disease Occupational Lung Disease Pathogens Surveillance

  More +
• ISSN:
  1529-7322
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  12 pdf pages
• Volume:
  23
• NIOSHTIC Number:
  nn:20067539
• Citation:
  Curr Allergy Asthma Rep 2023 Jun; 23(6):313-324
• Contact Point Address:
  Aaron D. Schwab, Division of Allergy and Immunology, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE
• Email:
  aaron.schwab@unmc.edu
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center - Omaha
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Current Allergy & Asthma Reports
• End Date:
  20270831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a188d5562a2245854ac22ad2502f4a213b8aa1e956a275d8395e9658087f962de9ab296bcfe137bc744c8cb9ef86e726535103dc8586ce7a009abb6c72a61624
• Download URL:
  https://stacks.cdc.gov/view/cdc/230736/cdc_230736_DS1.pdf
• File Type:
  [PDF - 1.72 MB ]