Mechanistic and therapeutic approaches to occupational exposure-associated allergic and non-allergic asthmatic disease

Details

• Alternative Title:
  Curr Allergy Asthma Rep
• Personal Author:
  Schwab, Aaron D. ; Poole, Jill A.
• Description:
  Purpose of Review
  
  Occupational lung disease, including asthma, is a significant cause of disability worldwide. The dose, exposure frequency, and nature of the causal agent influence the inflammatory pathomechanisms that inform asthma disease phenotype and progression. While surveillance, systems engineering, and exposure mitigation strategies are essential preventative considerations, no targeted medical therapies are currently available to ameliorate lung injury post-exposure and prevent chronic airway disease development.
  
  Recent Findings
  
  This article reviews contemporary understanding of allergic and non-allergic occupational asthma mechanisms. In addition, we discuss the available therapeutic options, patient-specific susceptibility and prevention measures, and recent scientific advances in post-exposure treatment conception.
  
  Summary
  
  The course of occupational lung disease that follows exposure is informed by individual predisposition, immunobiologic response, agent identity, overall environmental risk, and preventative workplace practices. When protective strategies fail, knowledge of underlying disease mechanisms is necessary to inform targeted therapy development to lessen occupational asthma disease severity and occurrence.
  
  
• Subjects:
  Asthma, Occupational Humans Hypersensitivity Occupational Diseases Occupational Exposure Pulmonary Disease, Chronic Obstructive
• Keywords:
  Airway Hyperresponsiveness Allergy Asthma Immunotherapy Inflammation Occupational Lung Disease
• Source:
  Curr Allergy Asthma Rep. 23(6):313-324
• Pubmed ID:
  37154874
• Pubmed Central ID:
  PMC10896074
• Document Type:
  Journal Article
• Funding:
  R01 OH012045/OH/NIOSH CDC HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/ ; U54OH010162/ACL/ACL HHSUnited States/
• Volume:
  23
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6176fa636e6c8751c4bfeae7cb2b9b6340085530bab44589a8032a7229f1b392
• Download URL:
  https://stacks.cdc.gov/view/cdc/150347/cdc_150347_DS1.pdf
• File Type:
  [PDF - 680.65 KB ]