Cerebral Blood Vessel Damage in Traumatic Brain Injury

Details

• Personal Author:
  Converse, Matthew I. ; Manley, Geoffrey T. ; Monson, Kenneth L.
• Description:
  Traumatic brain injury is a devastating cause of death and disability. Although injury of brain tissue is of primary interest in head trauma, nearly all significant cases include damage of the cerebral blood vessels. Because vessels are critical to the maintenance of the healthy brain, any injury or dysfunction of the vasculature puts neural tissue at risk. It is well known that these vessels commonly tear and bleed as an immediate consequence of traumatic brain injury. It follows that other vessels experience deformations that are significant though not severe enough to produce bleeding. Recent data show that such subfailure deformations damage the microstructure of the cerebral vessels, altering both their structure and function. Little is known about the prognosis of these injured vessels and their potential contribution to disease development. The objective of this review is to describe the current state of knowledge on the mechanics of cerebral vessels during head trauma and how they respond to the applied loads. Further research on these topics will clarify the role of blood vessels in the progression of traumatic brain injury and is expected to provide insight into improved strategies for treatment of the disease. [Description provided by NIOSH]
• Subjects:
  Blood Nervous System Occupational Health Safety
• Keywords:
  Author Keywords: Traumatic Brain Injury Biomechanics Blood Vessels Brain Matter Cerebral Blood Vessel Damage Cerebrovascular System Disorders Head Injuries Neuropathology TBI Traumatic Brain Injury
• ISSN:
  0268-0033
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 8 ; OSHA Region 9 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  16 pdf pages
• Volume:
  64
• NIOSHTIC Number:
  nn:20067280
• Citation:
  Clin Biomech 2019 Apr; 64:98-113
• Contact Point Address:
  Kenneth L. Monson, 1495 E. 100 S., MEK 1550, Salt Lake City, UT 84112, USA
• Email:
  ken.monson@utah.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Clinical Biomechanics
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2f42834606603a89b26ac5d0a92bb93467ea4619405342da27ee3cb7279d37738501ed59cf2a4d8f4eb4e8e0f500fd79bfb223570ad2481685de6781ec72766
• Download URL:
  https://stacks.cdc.gov/view/cdc/230615/cdc_230615_DS1.pdf
• File Type:
  [PDF - 2.46 MB ]