Material Properties of Rat Middle Cerebral Arteries at High Strain Rates

Details

• Personal Author:
  Bell DE ; Converse M ; Mao H ; Monson KL ; Reifman J ; Unnikrishnan G
• Description:
  Traumatic brain injury (TBI), resulting from either impact- or nonimpact blast-related mechanisms, is a devastating cause of death and disability. The cerebral blood vessels, which provide critical support for brain tissue in both health and disease, are commonly injured in TBI. However, little is known about how vessels respond to traumatic loading, particularly at rates relevant to blast. To better understand vessel responses to trauma, the objective of this project was to characterize the high-rate response of passive cerebral arteries. Rat middle cerebral arteries (MCAs) were isolated and subjected to high-rate deformation in the axial direction. Vessels were perfused at physiological pressures and stretched to failure at strain rates ranging from approximately 100 to 1300 s-1. Although both in vivo stiffness and failure stress increased significantly with strain rate, failure stretch did not depend on rate. [Description provided by NIOSH]
• Subjects:
  Animals Biomechanical Phenomena Blood Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: Traumatic Brain Injury Biomechanics Blast Injuries Blast Injury Blood Vessel Mechanical Properties Blood Vessels Cerebrovascular System Disorders High Strain Rate Testing TBI Traumatic Brain Injury

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• ISSN:
  0148-0731
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  140
• Issue:
  7
• NIOSHTIC Number:
  nn:20067279
• Citation:
  J Biomech Eng 2018 Jul; 140(7):071004
• Contact Point Address:
  Kenneth L. Monson, Department of Mechanical Engineering, University of Utah, 1495 E. 100 S., MEK 1550, Salt Lake City, UT 84112
• Email:
  ken.monson@utah.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Biomechanical Engineering
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d3779aa127bd19a347993514bd40c139d525caf458a8982b70c8200b699d7cf51faf4505ede98bda39704e03a37aa14c325014fa4266d1c8463917d13457b08d
• Download URL:
  https://stacks.cdc.gov/view/cdc/231386/cdc_231386_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]