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Chronic Wasting Disease Agents in Nonhuman Primates
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  1. Susceptibilities of Nonhuman Primates to Chronic Wasting Disease
    Personal Author:
    Race, Brent; Meade-White, Kimberly D.; Miller, Michael W.; Barbian, Kent D.; Rubenstein, Richard; LaFauci, Giuseppe; Cervenakova, Larisa; Favara, Cynthia; Gardner, Donald; Long, Dan; Parnell, Michael; Striebel, James; Priola, Suzette A.; Ward, Anne; Williams, Elizabeth S.; Race, Richard; Chesebro, Bruce;
    Published:
    Sep 2009
    Source:
    Emerg Infect Dis. 15(9):1366-1376.
    Description:
    Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids. We used 2 nonhuman primate ...
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    Filetype[PDF - 775.62 KB]
  2. Foodborne Transmission of Bovine Spongiform Encephalopathy to Nonhuman Primates
    Personal Author:
    Holznagel, Edgar; Yutzy, Barbara; Schulz-Schaeffer, Walter; Kruip, Carina; Hahmann, Uwe; Bierke, Pär; Torres, Juan-Maria; Kim, Yong-Sun; Thomzig, Achim; Beekes, Michael; Hunsmann, Gerhard; Loewer, Johannes;
    Published:
    May 2013
    Source:
    Emerg Infect Dis. 19(5):712-720.
    Description:
    Risk for human exposure to bovine spongiform encephalopathy (BSE)-inducing agent was estimated in a nonhuman primate model. To determine attack rates, incubation times, and molecular signatures, we orally exposed 18 macaques to 1 high dose of brain m...
    File Type:
    Filetype[PDF - 2.71 MB]
  3. U.S. Public Health Service guideline on infectious disease issues in xenotransplantation
    Corporate Author:
    Center for Biologics Evaluation and Research (U.S.); Centers for Diseases Control and Prevention (U.S.); National Center for Infectious Diseases (U.S.); United States, Department of Health, Education, and Welfare., Office of the Assistant Secretary for Planning and Evaluation; United States, Health Resources and Services Administration.;
    Published:
    August 24, 2001
    Series:
    MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports ; v. 50, no. RR-15
    Description:
    Several developments have fueled the renewed interest in xenotransplantation--the use of live animal cells, tissues and organs in the treatment or mitigation of human disease. The world-wide, critical shortage of human organs available for transplant...
    Status:
    current
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    Filetype[PDF - 256.27 KB]
  4. MMWR. Morbidity and mortality weekly report, Vol. 37, no. 45, November 18, 1988
    Corporate Author:
    Centers for Disease Control (U.S.)
    Published:
    November 18, 1988
    Series:
    MMWR. Morbidity and mortality weekly report ; v. 37, no. 45
    Description:
    State-specific estimates of smoking-attributable mortality and years of potential life lost--United States, 1985 -- Guidelines to prevent simian immunodeficiency virus infection in laboratory workers and animal handlers -- Table I. Summary-cases spec...
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  5. Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
    Personal Author:
    Herbst, Allen; Velásquez, Camilo Duque; Triscott, Elizabeth; Aiken, Judd M.; McKenzie, Debbie;
    Published:
    Sep 2017
    Source:
    Emerg Infect Dis. 23(9):1598-1600.
    Description:
    Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95(+), into mice resulted in infection. Thus, emerge...
    File Type:
    Filetype[PDF - 282.89 KB]