Persistence and Complex Evolution of Fluoroquinolone-Resistant Streptococcus pneumoniae Clone

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ben-David, Debby ; Schwaber, Mitchell J. ; Adler, Amos ; Masarwa, Samira ; Edgar, Rotem ; Navon-Venezia, Shiri ; Schwartz, David ; Porat, Nurith ; Kotlovsky, Tali ; Polivkin, Nikolay ; Weinberg, Irina ; Lazary, Avraham ; Ohana, Nissim ; Dagan, Ron
• Description:
  Prolonged outbreaks of multidrug-resistant Streptococcus pneumoniae in health care facilities are uncommon. We found persistent transmission of a fluroquinolone-resistant S. pneumoniae clone during 2006-2011 in a post-acute care facility in Israel, despite mandatory vaccination and fluoroquinolone restriction. Capsular switch and multiple antimicrobial nonsusceptibility mutations occurred within this single clone. The persistent transmission of fluoroquinolone-resistant S. pneumoniae during a 5-year period underscores the importance of long-term care facilities as potential reservoirs of multidrug-resistant streptococci.
• Subjects:
  Antimicrobial Drug Resistance Bacteria Clonal Evolution Fluoroquinolones Long-term Acute Care Hospital Research Streptococcus Pneumoniae
• Source:
  Emerg Infect Dis. 20(5):799-805.
• Document Type:
  Journal Article
• Volume:
  20
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:03fae63b3606ce85c1e90f0ec43d95fa81dd1e7d27cbcad5bbfdc07104036967
• Download URL:
  https://stacks.cdc.gov/view/cdc/23045/cdc_23045_DS1.pdf
• File Type:
  [PDF - 467.84 KB ]