Per- and Polyfluoroalkyl Substances (PFAS) and Lipid Trajectories in Women 45–56 Years of Age: The Study of Women’s Health Across the Nation

Details

• Personal Author:
  Calafat, Antonia M. ; Ding N ; Kang H ; Karvonen-Gutierrez CA ; Murkherjee B ; Park SK
• Description:
  Background: Per- and polyfluoroalkyl substances (PFAS) are associated with less favorable blood lipid profiles in epidemiological studies. However, little is known about the potential role of PFAS in longitudinal changes in lipids among midlife women even though women become more susceptible to metabolic alterations during the menopausal transition. Objectives: To examine associations of serum PFAS concentrations with longitudinal trajectories of blood total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides in midlife women undergoing menopausal transition. Methods: The sample included 1,130 women from the Study of Women's Health Across the Nation 45-56 y of age at baseline (1999-2000). We measured serum PFAS concentrations including linear perfluorooctanoic acid (n-PFOA), perfluorononanoic acid (PFNA), linear and branched perfluorooctanesulfonic acid (n-PFOS and Sm-PFOS, respectively), and perfluorohexanesulfonic acid (PFHxS) at baseline. We used k-means clustering to identify subgroups with different patterns of PFAS mixture. Blood lipids were measured annually or biannually through 2016 with an average follow-up of 14.8 y. We identified longitudinal trajectories of each lipid using latent class growth models. We used multinomial log-linear models adjusted for covariates to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of lipid trajectory classes by PFAS and their mixtures. Results: Three distinct trajectories (low, middle, high) of total, LDL, and HDL cholesterol and two distinct trajectories (low and high) of triglycerides were identified. n-PFOS, Sm-PFOS, and PFHxS were positively associated with total and LDL cholesterol trajectories. n-PFOS was inversely associated with triglycerides trajectories. PFAS mixtures (high vs. low) showed positive associations with total and LDL cholesterol trajectories (high vs. low), showing ORs (95% CIs) of 1.69 (95% CI: 1.36, 2.12) and 1.79 (95% CI: 1.44, 2.22), respectively. Discussion: Concentrations of serum PFAS were positively associated with trajectories of total and LDL cholesterol, providing a line of evidence supporting adverse effects of PFAS on lipid homeostasis. [Description provided by NIOSH]
• Subjects:
  Aging Environmental Exposure Environmental Pollution Epidemiology Lipids Occupational Health Safety Women
• Keywords:
  Age Groups Environmental Pollution Longitudinal Study Metabolic Rate Per- And Polyfluoroalkyl Substances PFAS
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Michigan ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  131
• Issue:
  8
• NIOSHTIC Number:
  nn:20068221
• Citation:
  Environ Health Perspect 2023 Aug; 131(8):87004
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109-2029
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Perfluorocarbons (CAS RN 308069-13-8)
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6902511d3fba1b9038b9ac6783c80874b9070d5b2709dbbe7955fd44277ca51aa292274e4ee9f074757ba3a89d5ebb626896ed4c63140ccd392cbcd09a806ec1
• Download URL:
  https://stacks.cdc.gov/view/cdc/230424/cdc_230424_DS1.pdf
• File Type:
  [PDF - 992.18 KB ]