Per- and Polyfluoroalkyl Substances (PFAS) and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women’s Health Across the Nation

Details

• Journal Article:
  Hypertension
• Personal Author:
  Ding, Ning ; Karvonen-Gutierrez, Carrie A. ; Mukherjee, Bhramar ; Calafat, Antonia M. ; Harlow, Siobán D. ; Park, Sung Kyun
• Description:
  Background:
  
  Per- and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals that may disrupt blood pressure controls; however, human evidence to support this hypothesis is scant. We examined the association between serum concentrations of PFAS and risks of developing hypertension.
  
  Methods:
  
  This study included 1,058 midlife women initially free of hypertension from the multi-racial/ethnic Study of Women’s Health Across the Nation (SWAN) with annual follow-up visits between 1999 and 2017. Hypertension was defined as blood pressure ≥140 mmHg systolic or ≥90 mmHg diastolic or receiving anti-hypertensive treatment. Cox proportional hazards models were utilized to calculate hazards ratios (HRs) and 95% confidence intervals (CIs). Quantile g-computation was implemented to evaluate the joint effect of PFAS mixtures.
  
  Results:
  
  During 11,722 person-years of follow-up, 470 participants developed incident hypertension (40.1 cases per 1000 person-years). Compared with the lowest tertile, women in the highest tertile of baseline serum concentrations had adjusted HRs of 1.42 (95% CI: 1.19–1.68) for perfluorooctane sulfonate (PFOS) (P-trend=0.01), 1.47 (95% CI: 1.24–1.75) for linear perfluorooctanoate (n-PFOA) (P-trend=0.01), and 1.42 (95% CI: 1.19–1.70) for 2-(N-ethyl-perfluorooctane sulfonamido) acetate (EtFOSAA) (P-trend=0.01). No significant associations were observed for perfluorononanoate (PFNA) and perfluorohexane sulfonate (PFHxS). In the mixture analysis, women in the highest tertile of overall PFAS concentrations had an HR of 1.71 (95% CI: 1.15–2.54) (P-trend=0.008), compared with those in the lowest tertile.
  
  Conclusions:
  
  Several PFAS showed positive associations with incident hypertension. These findings suggest that PFAS might be an underappreciated contributing factor to women’s cardiovascular disease risk.
  
  
• Subjects:
  Blood Pressure Environmental Pollutants Female Fluorocarbons Hypertension Occupational Health Safety Women's Health
• Keywords:
  Author Keywords: Blood Pressure; Cardiovascular Disease; Hypertension; Perfluorocarbon; Perfluorooctanoic Acid; Perfluorooctane Sulfonic Acid; Women Women; Hypertension; Blood Pressure; Cardiovascular Disease; Age Groups; Per- And Polyfluoroalkyl Substances; PFAS; Environmental Pollution; Epidemiology; Health Effects;
• Source:
  Hypertension. 79(8):1876-1886
• Pubmed ID:
  35695012
• Pubmed Central ID:
  PMC9308661
• Document Type:
  Text
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; R01 AG062622/AG/NIA NIH HHSUnited States/ ; P30 DK092926/DK/NIDDK NIH HHSUnited States/ ; U01 AG012554/AG/NIA NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; U01 AG012505/AG/NIA NIH HHSUnited States/ ; U01 AG012535/AG/NIA NIH HHSUnited States/ ; U01 AG012553/AG/NIA NIH HHSUnited States/ ; U01 NR004061/NR/NINR NIH HHSUnited States/ ; U01 AG012539/AG/NIA NIH HHSUnited States/ ; R01 ES026578/ES/NIEHS NIH HHSUnited States/ ; U01 AG012546/AG/NIA NIH HHSUnited States/ ; U19 AG063720/AG/NIA NIH HHSUnited States/ ; U01 AG012495/AG/NIA NIH HHSUnited States/ ; U01 AG012531/AG/NIA NIH HHSUnited States/ ; R01 ES026964/ES/NIEHS NIH HHSUnited States/ ; U01 AG017719/AG/NIA NIH HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Michigan ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  21 pdf pages
• Volume:
  79
• Issue:
  8
• NIOSHTIC Number:
  nn:20065689
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:08cc63d62193a685bca8480baadea050d12759493870b797d5254c4e301cd9ee2a10aa4d1b1831fa34104fcb0eec93315f4995bdf50d97cf39802175bab43662
• Download URL:
  https://stacks.cdc.gov/view/cdc/119640/cdc_119640_DS1.pdf
• File Type:
  [PDF - 482.59 KB ]