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Per- and Polyfluoroalkyl Substances (PFAS) and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women’s Health Across the Nation
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8 2022
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Source: Hypertension. 79(8):1876-1886
[PDF-482.59 KB]
Details:
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Alternative Title:Hypertension
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Personal Author:
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Description:Background:
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals that may disrupt blood pressure controls; however, human evidence to support this hypothesis is scant. We examined the association between serum concentrations of PFAS and risks of developing hypertension.
Methods:
This study included 1,058 midlife women initially free of hypertension from the multi-racial/ethnic Study of Women’s Health Across the Nation (SWAN) with annual follow-up visits between 1999 and 2017. Hypertension was defined as blood pressure ≥140 mmHg systolic or ≥90 mmHg diastolic or receiving anti-hypertensive treatment. Cox proportional hazards models were utilized to calculate hazards ratios (HRs) and 95% confidence intervals (CIs). Quantile g-computation was implemented to evaluate the joint effect of PFAS mixtures.
Results:
During 11,722 person-years of follow-up, 470 participants developed incident hypertension (40.1 cases per 1000 person-years). Compared with the lowest tertile, women in the highest tertile of baseline serum concentrations had adjusted HRs of 1.42 (95% CI: 1.19–1.68) for perfluorooctane sulfonate (PFOS) (P-trend=0.01), 1.47 (95% CI: 1.24–1.75) for linear perfluorooctanoate (n-PFOA) (P-trend=0.01), and 1.42 (95% CI: 1.19–1.70) for 2-(N-ethyl-perfluorooctane sulfonamido) acetate (EtFOSAA) (P-trend=0.01). No significant associations were observed for perfluorononanoate (PFNA) and perfluorohexane sulfonate (PFHxS). In the mixture analysis, women in the highest tertile of overall PFAS concentrations had an HR of 1.71 (95% CI: 1.15–2.54) (P-trend=0.008), compared with those in the lowest tertile.
Conclusions:
Several PFAS showed positive associations with incident hypertension. These findings suggest that PFAS might be an underappreciated contributing factor to women’s cardiovascular disease risk.
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Pubmed ID:35695012
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Pubmed Central ID:PMC9308661
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Volume:79
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Issue:8
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