Inhalation of Polycarbonate Emissions Generated During 3D Printing Processes Affects Neuroendocrine Function in Male Rats (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  Download the Dataset decsribed here from Data.cdc.gov at https://doi.org/10.26616/NIOSHRD-1069-2023-0.
  
  Three-dimensional printing (3DP) of manufactured goods has increased in the last 10 yrs. The increased use of this technology has resulted in questions about the health effects of inhaling emissions generated during printing. The goal of this study was to determine if inhalation of particulate and toxic chemicals generated during printing with polycarbonate (PC) plastic affected the neuroendocrine system. Male rats were exposed to 3D-printer emissions (500 µg/cm3) or filtered air for 1, 4, 8, 15 or 30d for 4d/week (4h/day). The effects of these exposures on hormone concentrations, and markers of function, injury and/or oxidative stress in the olfactory bulb, hypothalamus and testes were measured after 1, 8 and 30d of exposure. Thirty days of exposure to 3D-emissions resulted in reductions in thyroid stimulating hormone, follicle stimulating hormone and prolactin. These changes were accompanied by increases in markers of cell injury and reductions in active mitochondria in the olfactory bulb, gonadotropin releasing hormone cells and fibers and tyrosine hydroxylase immunolabeled fibers in the arcuate nucleus, and reductions in spermatogonium. PC plastics contain high concentrations bisphenol A and these results are consistent with the hypothesis that the health effects of inhaling 3D-printer emissions may be due to bisphenol A. [Description provided by NIOSH]
  
  
• Subjects:
  Animals Histology Occupational Health Plastics Printing, Three-Dimensional Respiratory System Safety
• Keywords:
  3D Printing Animal Studies Emission Sources Endocrine Function Hormone Activity Inhalation Studies Neurological System Three Dimensional Printing
• Series:
  NIOSH Data
• DOI:
  https://doi.org/10.26616/NIOSHRD-1069-2023-0
• Landing Page:
  https://stacks.cdc.gov/view/cdc/230108
• Dataset Download URL:
  https://data.cdc.gov/download/dtz3-sij3/application%2Fx-zip-compressed
• Identifier:
  https://doi.org/10.26616/NIOSHRD-1069-2023-0
• Format:
  ZIP folder
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• Media Type:
  application/zip
• Described By Type:
  HTML Repository Page
• License:
  https://creativecommons.org/public-domain/
• Rights:
  Public Domain
• Described By:
  https://stacks.cdc.gov/view/cdc/230108
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Contact Point:
  Health Effects Laboratory Division (HELD). Physical Effects Research Branch (PERB)
• Pages in Document:
  1 ZIP folder
• NIOSHTIC Number:
  nn:20067869
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1069-2023-0, 2023 Jul; :dataset
• Email:
  sa-cin-webteam@cdc.gov
• CAS Registry Number:
  Polycarbonates (CAS RN 25766-59-0)
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f7fc8061947e8caefe919e3bdb7f0e95f77285a44ecbe4bce232eaf3ab12046b0659b25a88a849ce9a9e3b0605fd5c6d6f3b4f0e166d37f45bdeff01b312bb2f
• Download URL:
  https://stacks.cdc.gov/view/cdc/230108/cdc_230108_DS1.pdf
• File Type:
  [PDF - 453.40 KB ]