Isomer-Specific Serum Concentrations of Perfluorooctane Sulfonic Acid Among U.S. Adults: Results from the National Health and Nutrition Examination Survey (NHANES) and the Study of Women’s Health Across the Nation Multi-Pollutant Study (SWAN-MPS)

Details

• Personal Author:
  Calafat, Antonia M. ; Kang H ; Karvonen-Gutierrez CA ; Park SK
• Description:
  Electrochemical fluorination manufacture of perfluorooctane sulfonic acid (PFOS), one of the most studied per- and polyfluoroalkyl substances, produces mixtures of linear and branched isomers, but little is known about human exposure to linear or branched PFOS isomers. We examined determinants affecting isomer-specific patterns of PFOS in serum in two adult populations in the United States, the National Health and Nutrition Examination Survey (NHANES) and the Study of Women's Health Across the Nation Multi-Pollutant Study (SWAN-MPS). After adjusting for demographic variables, fish consumption (in both populations), a glomerular filtration rate above 90 mL/min/1.73 m2 (observed in NHANES; not tested in SWAN-MPS), premenopausal status (only observed in SWAN-MPS), and less consumption of processed food (observed in SWAN-MPS; not tested in NHANES) were associated with a higher proportion of linear PFOS. Non-Hispanic Black and Asian participants were likely to have a higher proportion of linear PFOS than non-Hispanic White participants in both populations. Our findings suggest that isomer-specific patterns of PFOS serum concentrations in humans vary depending on population characteristics that affect PFOS exposure and excretion. Consideration of specific PFOS isomers in future human biomonitoring and epidemiologic studies can provide useful insight to better understand PFOS exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cohort Studies Environmental Exposure Epidemiology Occupational Health Safety Women
• Keywords:
  Air Pollution Author Keywords: PFAS Branched Cohort Studies Dietary Effects Electrochemical Fluorination Environmental Exposure Food Contaminants Glomerular Filtration Kidney Function Longitudinal Study Menopause Menstruation Per- And Polyfluoroalkyl Substances PFAS Processed Food Seafood

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• ISSN:
  0013-936X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Michigan ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  385-394
• Volume:
  57
• Issue:
  1
• NIOSHTIC Number:
  nn:20067776
• Citation:
  Environ Sci Technol 2023 Jan; 57(1):385-394
• Contact Point Address:
  Habyeong Kang, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, United States
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Perfluorooctanesulfonic acid (CAS RN 1763-23-1)
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Science and Technology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:df7b426bec95f0f615649dc46718fe92cf6cbc48593f27d5d017a3ee722d19ebc101c8012dfbe1d35a084709b6377368f75396cb4601a7c4936624ddf2b3846f
• Download URL:
  https://stacks.cdc.gov/view/cdc/230036/cdc_230036_DS1.pdf
• File Type:
  [PDF - 1.66 MB ]