Details:

Alternative Title:
Br J Cancer
Publisher's site:
http://dx.doi.org/10.1038/bjc.2011.359
Personal Author:
Johnson, K J ; Carozza, S E ; Chow, E J ; Fox, E E ; Horel, S ; ... More +
Johnson, K J ; Carozza, S E ; Chow, E J ; Fox, E E ; Horel, S ; McLaughlin, C C ; Mueller, B A ; Puumala, S E ; Reynolds, P ; Von Behren, J ; Spector, L G ; Less -
Description:
Background: Carcinomas in children are rare and have not been well studied. Methods: We conducted a population-based case–control study and examined associations between birth characteristics and childhood carcinomas diagnosed from 28 days to 14 years during 1980–2004 using pooled data from five states (NY, WA, MN, TX, and CA) that linked their birth and cancer registries. The pooled data set contained 57 966 controls and 475 carcinoma cases, including 159 thyroid and 126 malignant melanoma cases. We used unconditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: White compared with ‘other' race was positively associated with melanoma (OR=3.22, 95% CI 1.33–8.33). Older maternal age increased the risk for melanoma (ORper 5-year age increase=1.20, 95% CI 1.00–1.44), whereas paternal age increased the risk for any carcinoma (OR=1.10per 5-year age increase, 95% CI 1.01–1.20) and thyroid carcinoma (ORper 5-year age increase=1.16, 95% CI 1.01–1.33). Gestational age <37 vs 37–42 weeks increased the risk for thyroid carcinoma (OR=1.87, 95% CI 1.07–3.27). Plurality, birth weight, and birth order were not significantly associated with childhood carcinomas. Conclusion: This exploratory study indicates that some birth characteristics including older parental age and low gestational age may be related to childhood carcinoma aetiology.
Subject:
[+]
Adolescent
Birth Order
Birth Weight
Carcinoma
Case-Control Studies
Child
Child, Preschool
Epidemiology
Female
Gestational Age
Humans
Infant
Infant, Newborn
Male
Maternal Age
Melanoma
Neoplasms
Paediatric
Paternal Age
Risk
Thyroid
Thyroid Neoplasms
Melanoma
Risk

Source:
Br J Cancer. 2011 ; 105(9):1396-1401.;
Pubmed ID:
21915125
Pubmed Central ID:
PMC3241539
Document Type:
Journal Article ;
Funding:
N01-CN-0523/CN/NCI NIH HHS/United States ; R01CA71745/CA/NCI NIH HHS/United States ; R01CA92670/CA/NCI NIH HHS/United States ; T32 CA099936/CA/NCI NIH HHS/United States ; T32 CA099936/CA/NCI NIH HHS/United States ; ... More +
N01-CN-0523/CN/NCI NIH HHS/United States ; R01CA71745/CA/NCI NIH HHS/United States ; R01CA92670/CA/NCI NIH HHS/United States ; T32 CA099936/CA/NCI NIH HHS/United States ; T32 CA099936/CA/NCI NIH HHS/United States ; U58DP000783-01/DP/NCCDPHP CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7cb9a8f2aab858183e5a340e5626bab15cab744468e407268aefff4ea98f17bf
File Type:

Supporting Files

• 	bjc2011359a.nxml	txt
  	bjc2011359x1.doc	doc
  	license.txt	txt

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