High Birth Weight, Early UV Exposure, and Melanoma Risk in Children, Adolescents and Young Adults

Details

• Alternative Title:
  Epidemiology
• Personal Author:
  Wojcik, Katherine Y ; Escobedo, Loraine A. ; Wysong, Ashley ; Heck, Julia E ; Ritz, Beate ; Hamilton, Ann S ; Milam, Joel ; Cockburn, Myles G
• Description:
  Background:
  
  Melanoma, the deadliest form of skin cancer, is the second most common cancer diagnosed before age 30. Little is known about potentially modifiable or intervenable risk factors specific to developing melanoma at a young age. The objective was to determine if high birth weight or higher early life ultraviolet (UV) radiation exposure would be associated with increased risk of melanoma in young patients.
  
  Methods:
  
  Population-based, case–control study of 1,396 cases of melanoma diagnosed before age 30 in 1988-2013 and 27,920 controls, obtained by linking cancer registry data to birth records in California.
  
  Results:
  
  High birth weight (>4000g) was associated with 19% higher risk of melanoma (OR:1.19; 95% CI: 1.02, 1.39), while low birth weight (<2500g) was associated with 41% lower risk (OR:0.59; 95% CI: 0.43, 0.82), compared to normal birth weight (2500-4000g); dose–response per 1000g increase was also evident (OR:1.24; 95% CI:1.13, 1.36). All quartiles of birthplace UV greater than the lowest quartile were associated with increased melanoma risk. The strongest relationship between birthplace UV and melanoma was for 15-19 years of age at diagnosis.
  
  Conclusions:
  
  High birth weight and high early-life UV exposure may be important independent risk factors for melanoma diagnosis before age 30. The implication is that adopting skin-protective behaviors as early as infancy could be important for primary prevention of melanoma in younger people. However, research that accounts for early-life behavioral patterns of skin protection during infancy is needed to advance our understanding of how birth weight and early-life UV may influence development of early onset melanoma.
  
  
• Subjects:
  Adolescent Adult Birth Weight Case-Control Studies Child Child, Preschool Environmental Exposure Female Humans Male Melanoma Race Factors Risk Risk Factors Skin Neoplasms Ultraviolet Rays Young Adult

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• Keywords:
  Birthweight Case-control Studies Pediatrics Records-based Registries Skin Cancer Skin Neoplasms Solar Radiation
• Source:
  Epidemiology. 30(2):278-284
• Pubmed ID:
  30499783
• Pubmed Central ID:
  PMC6435257
• Document Type:
  Journal Article
• Funding:
  P30 ES007048/ES/NIEHS NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; P30 CA046934/CA/NCI NIH HHSUnited States/ ; R21 ES019986/ES/NIEHS NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; R01 CA195218/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; T32 CA092408/CA/NCI NIH HHSUnited States/ ; R21 ES018960/ES/NIEHS NIH HHSUnited States/ ; T32 CA009492/CA/NCI NIH HHSUnited States/ ; R01 CA158407/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/
• Place as Subject:
  California
• Volume:
  30
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e690dd7975c3d325e5845612404eae46a03397bbb9668f81c8c257fc90e80a85
• Download URL:
  https://stacks.cdc.gov/view/cdc/77011/cdc_77011_DS1.pdf
• File Type:
  [PDF - 95.25 KB ]