Neonatal jaundice in association with autism spectrum disorder and developmental disorder

Details

• Alternative Title:
  J Perinatol
• Personal Author:
  Cordero, Christina ; Schieve, Laura A. ; Croen, Lisa A. ; Engel, Stephanie M. ; Siega-Riz, Anna Maria ; Herring, Amy H. ; Vladutiu, Catherine J. ; Seashore, Carl J. ; Daniels, Julie L.
• Description:
  Objective
  
  To examine the association between neonatal jaundice and autism spectrum disorder (ASD) and non-ASD developmental disorder (DD).
  
  Study design
  
  We analyzed data from the Study to Explore Early Development, a US multisite, case-control study conducted from 2007 to 2011. Developmental assessment classified children aged 2–5 years into: ASD (n= 636), DD (n= 777), or controls (POP; n= 926). Neonatal jaundice (n= 1054) was identified from medical records and maternal interviews. We examined associations between neonatal jaundice and ASD and DD using regression models to obtain adjusted odds ratios (aOR).
  
  Results
  
  Our results showed interaction between gestational age and neonatal jaundice. Neonatal jaundice was associated with ASD at 35–37 weeks (aOR = 1.83, 95%CI 1.05, 3.19), but not ≥38 weeks gestation (aOR = 0.97, 95%CI 0.76, 1.24). Similar results were observed with DD.
  
  Conclusions
  
  Further exploration of timing and severity of neonatal jaundice and ASD/DD is warranted.
  
  
• Keywords:
  Adult Age Factors Autism Spectrum Disorder Case-Control Studies Child, Preschool Developmental Disabilities Female Gestational Age Humans Infant, Premature Jaundice, Neonatal Male Maternal Age Odds Ratio Young Adult

  More +
• Source:
  J Perinatol. 40(2):219-225
• Pubmed ID:
  31388117
• Pubmed Central ID:
  PMC7031756
• Document Type:
  Journal Article
• Funding:
  T32 HD052468/HD/NICHD NIH HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD000750/DD/NCBDD CDC HHSUnited States/ ; U10 DD000182/DD/NCBDD CDC HHSUnited States/ ; U01DD000750/ACL/ACL HHSUnited States/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/ ; P30 ES010126/ES/NIEHS NIH HHSUnited States/ ; U10 DD000180/DD/NCBDD CDC HHSUnited States/
• Volume:
  40
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8b51c479930841aa5010c70e5a2767a44ceeadd2cec133ba8c765c170551e960
• Download URL:
  https://stacks.cdc.gov/view/cdc/85255/cdc_85255_DS1.pdf
• File Type:
  [PDF - 422.74 KB ]