Global Epidemiology and Evolutionary History of Staphylococcus aureus ST45

Details

• Personal Author:
  Altinok O ; Bletz S ; Coombs GW ; Effelsberg N ; Heaney CD ; Kearns A ; Mellmann A ; Peitzmann L ; Pichon B ; Randad PR ; Schaumburg F ; Stegger M
• Description:
  Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. It is one of the most prevalent carrier lineages but also frequently causes severe invasive disease, such as bacteremia. Little is known about its evolutionary history. In this study, we used whole-genome sequencing to analyze a large collection of 451 diverse ST45 isolates from 6 continents and 26 countries. De novo-assembled genomes were used to understand genomic plasticity and to perform coalescent analyses. The ST45 population contained two distinct sublineages, which correlated with the isolates' geographical origins. One sublineage primarily consisted of European/North American isolates, while the second sublineage primarily consisted of African and Australian isolates. Bayesian analysis predicted ST45 originated in northwestern Europe about 500 years ago. Isolation time, host, and clinical symptoms did not correlate with phylogenetic groups. Our phylogenetic analyses suggest multiple acquisitions of the SCCmec element and key virulence factors throughout the evolution of the ST45 lineage. [Description provided by NIOSH]
• Subjects:
  Epidemiology Occupational Health Safety
• Keywords:
  Author Keywords: Staphylococcus Aureus Bacteria Bacterial Infections Evolution Genomics Infectious Agents Methicillin Resistant Staphylococcus Aureus MRSA MRSA Evolution Phylogeny ST45 Whole-genome Sequencing

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• ISSN:
  0095-1137
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  59
• Issue:
  1
• NIOSHTIC Number:
  nn:20062819
• Citation:
  J Clin Microbiol 2020 Dec; 59(1):e02198-20
• Email:
  mellmann@uni-muenster.de
• Federal Fiscal Year:
  2021
• Performing Organization:
  Johns Hopkins University, Baltimore, Maryland
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  Journal of Clinical Microbiology
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:34387bcb0ebc2b210e64ba8b46c1d8fb07cc0ac3384a5ac13d6bb9ae1facf574933ef4d3b8b4f583b5cec8e400f5ed478b37cd30a338d1402201ac87ea1468e3
• Download URL:
  https://stacks.cdc.gov/view/cdc/226001/cdc_226001_DS1.pdf
• File Type:
  [PDF - 1.84 MB ]