Effect of Modifying Quantum Dot Surface Charge on Airway Epithelial Cell Uptake In Vitro

Details

• Personal Author:
  Breysse PN ; Chau E ; Galloway JF ; Nelson A ; Searson PC ; Sidhaye VK ; Wirtz D
• Description:
  The respiratory system is one of the portals of entry into the body, and hence inhalation of engineered nanomaterials is an important route of exposure. The broad range of physicochemical properties that influence biological responses necessitate the systematic study to contribute to understanding occupational exposure. Here, we report on the influence of nanoparticle charge and dose on human airway epithelial cells, and show that this platform can be used to evaluate consequences of exposure to engineered nanomaterials. [Description provided by NIOSH]
• Subjects:
  Occupational Health Respiratory System Safety Toxicology
• Keywords:
  Airway Epithelial Cells Author Keywords: Nanoparticles Cellular Effects Epithelial Barrier Function Inhalation In Vitro Studies Nanomaterials Nanotoxicology Quantum Dots
• ISSN:
  1743-5390
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• Issue:
  6
• NIOSHTIC Number:
  nn:20062665
• Citation:
  Nanotoxicology 2013 Sep; 7(6):1143-1151
• Contact Point Address:
  Venkataramana K. Sidhaye, Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
• Email:
  vsidhay1@jhmi.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Nanotoxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:303899f7e61e2a8cab7bdba547946509224c3d1b0df5e4874ca83c7d725603fd5a73e4403f7d237bcdf58112aefa9a4e68022c909fcceca4fcea485a8de6c666
• Download URL:
  https://stacks.cdc.gov/view/cdc/225863/cdc_225863_DS1.pdf
• File Type:
  [PDF - 818.23 KB ]