Parental Occupation and Childhood Germ Cell Tumors: A Case-Control Study in Denmark, 1968–2016

Details

• Personal Author:
  Hall C ; Hansen J ; He D ; Heck JE ; Olsen J ; Ritz B ; von Ehrenstein OS
• Description:
  Purpose: To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). Methods: This population-based case-control study included childhood GCT cases in Denmark diagnosed 1968-2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). Results: Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23-4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94-14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30-4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77-2.95). Conclusion: Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors. [Description provided by NIOSH]
• Subjects:
  Epidemiology Neoplasms Occupational Health Safety Solvents
• Keywords:
  Author Keywords: Childhood Cancer Cancer Rates Case Control Studies Children Germ Cells JEM Job Exposure Matrix Organic Compounds Social Contact Teratoma Tumors Yolk Sac Tumor

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• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  8
• NIOSHTIC Number:
  nn:20062570
• Citation:
  Cancer Causes Control 2021 Aug; 32(8):827-836
• Contact Point Address:
  Julia E. Heck, Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA
• Email:
  julia.heck@unt.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Cancer Causes and Control
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:55ac2f30027d87b18a5d4d90af0f260d19233786b1a67620c727a585e89fa97940d07012ee0b2428a13df31a0fab40a35b5e20a704e123da436f3bd80bf330f7
• Download URL:
  https://stacks.cdc.gov/view/cdc/225787/cdc_225787_DS1.pdf
• File Type:
  [PDF - 565.23 KB ]