Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential

Details

• Personal Author:
  Chang CH ; Ji Z ; Li R ; Liao Y-P ; Lin S ; Meng H ; Nel AE ; Pinkerton KE ; Sun B ; Van Winkle L ; Wang M ; Wang X ; Xia, T. ; Zhang H ; Zink JI
• Description:
  Since more than 30% of consumer products that include engineered nanomaterials contain nano-Ag, the safety of this material is of considerable public concern. In this study, Ag nanoparticles (NPs) are used to demonstrate that 20 nm polyvinylpyrrolidone (PVP or P) and citrate (C)-coated Ag NPs induce more cellular toxicity and oxidative stress than larger (110 nm) particles due to a higher rate of dissolution and Ag bioavailability. Moreover, there is also a higher propensity for citrate 20 nm (C20) nanoparticles to generate acute neutrophilic inflammation in the lung and to produce chemokines compared to C110. P110 has less cytotoxic effects than C110, likely due to the ability of PVP to complex released Ag+. In contrast to the more intense acute pulmonary effects of C20, C110 induces mild pulmonary fibrosis at day 21, likely as a result of slow but persistent Ag+ release leading to a sub-chronic injury response. Interestingly, the released metallic Ag is incorporated into the collagen fibers depositing around airways and the lung interstitium. Taken together, these results demonstrate that size and surface coating affect the cellular toxicity of Ag NPs as well as their acute versus sub-chronic lung injury potential. [Description provided by NIOSH]
• Subjects:
  Immune System Lung Occupational Health Particulate Matter Respiratory System Safety Silver Toxicology
• Keywords:
  Author Keywords: Silver Cellular Effects Cytotoxicity Dissolution Immune Reaction Inhalation Lung Inflammation Nanomaterials Nanoparticle Nanoparticles Nanotoxicology Oxidative Stress Particle Size Pulmonary Effects

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• ISSN:
  1613-6810
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  385-398
• Volume:
  10
• Issue:
  2
• NIOSHTIC Number:
  nn:20062140
• Citation:
  Small 2014 Jan; 10(2):385-398
• Contact Point Address:
  André E. Nel, Division of NanoMedicine, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095 USA
• Email:
  anel@mednet.ucla.edu
• CAS Registry Number:
  2-Pyrrolidone (CAS RN 616-45-5) ; Citrate(3-) (CAS RN 126-44-3) ; Silver (CAS RN 7440-22-4)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Small
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4e266000e199fb00a0e03433ed5a36faeed73bf9d049f1de57334911bcf53bc9abf1da65902bd9ac9d6ae10100d7e8e898a8516bd590de9987e06489fa990803
• Download URL:
  https://stacks.cdc.gov/view/cdc/225447/cdc_225447_DS1.pdf
• File Type:
  [PDF - 510.52 KB ]