High Tuberculosis Prevalence in a South African Prison: The Need for Routine Tuberculosis Screening

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Telisinghe, Lilanganee ; Fielding, Katherine L. ; Malden, Justin L. ; Hanifa, Yasmeen ; Churchyard, Gavin J. ; Grant, Alison D. ; Charalambous, Salome
• Description:
  Background
  
  Tuberculosis is a major health concern in prisons, particularly where HIV prevalence is high. Our objective was to determine the undiagnosed pulmonary tuberculosis (“undiagnosed tuberculosis”) prevalence in a representative sample of prisoners in a South African prison. In addition we investigated risk factors for undiagnosed tuberculosis, to explore if screening strategies could be targeted to high risk groups, and, the performance of screening tools for tuberculosis.
  
  Methods and Findings
  
  In this cross-sectional survey, male prisoners were screened for tuberculosis using symptoms, chest radiograph (CXR) and two spot sputum specimens for microscopy and culture. Anonymised HIV antibody testing was performed on urine specimens. The sensitivity, specificity and predictive values of symptoms and investigations were calculated, using Mycobacterium tuberculosis isolated on sputum culture as the gold standard.
  
  Conclusions
  
  Undiagnosed tuberculosis and HIV prevalence was high in this prison, justifying routine screening for tuberculosis at entry into the prison, and intensified case finding among existing prisoners.
  
  
• Subjects:
  Adult Cross-Sectional Studies HIV Infections Humans Male Mass Screening Mycobacterium Tuberculosis Prevalence Prisoners Prisons Risk Factors Tuberculosis, Pulmonary

  More +
• Source:
  PLoS One. 2014; 9(1).
• DOI:
  http://dx.doi.org/10.1371/journal.pone.0087262
• Pubmed ID:
  24498059
• Pubmed Central ID:
  PMC3907552
• Document Type:
  Journal Article
• Funding:
  MR/K012126/1/Medical Research Council/United Kingdom ; PS024055/PS/NCHHSTP CDC HHS/United States ; PEPFAR/United States
• Name as Subject:
  United States. President's Emergency Plan For AIDS Relief (PEPFAR)
• Place as Subject:
  South Africa
• Volume:
  9
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:7947af7ef4e09c0cf12f5f08d573ca7b3546383e4709ac9fd5340045accafb8450d6ff5a40a3850f3040f96bb6f10b56c65ca7e29255209eb8c411461ac8de51
• Download URL:
  https://stacks.cdc.gov/view/cdc/22511/cdc_22511_DS1.pdf
• File Type:
  [PDF - 265.16 KB ]