Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0087262
Personal Author:
Telisinghe, Lilanganee ; Fielding, Katherine L. ; Malden, Justin L. ; Hanifa, Yasmeen ; Churchyard, Gavin J. ; ... More +
Telisinghe, Lilanganee ; Fielding, Katherine L. ; Malden, Justin L. ; Hanifa, Yasmeen ; Churchyard, Gavin J. ; Grant, Alison D. ; Charalambous, Salome Less -
Description:
Background

Tuberculosis is a major health concern in prisons, particularly where HIV prevalence is high. Our objective was to determine the undiagnosed pulmonary tuberculosis (“undiagnosed tuberculosis”) prevalence in a representative sample of prisoners in a South African prison. In addition we investigated risk factors for undiagnosed tuberculosis, to explore if screening strategies could be targeted to high risk groups, and, the performance of screening tools for tuberculosis.

Methods and Findings

In this cross-sectional survey, male prisoners were screened for tuberculosis using symptoms, chest radiograph (CXR) and two spot sputum specimens for microscopy and culture. Anonymised HIV antibody testing was performed on urine specimens. The sensitivity, specificity and predictive values of symptoms and investigations were calculated, using Mycobacterium tuberculosis isolated on sputum culture as the gold standard.

Conclusions

Undiagnosed tuberculosis and HIV prevalence was high in this prison, justifying routine screening for tuberculosis at entry into the prison, and intensified case finding among existing prisoners.


Subjects:
[+]
Adult Cross-Sectional Studies HIV Infections Humans Male Mass Screening Mycobacterium Tuberculosis Prevalence Prisoners Prisons Risk Factors Tuberculosis, Pulmonary
Source:
PLoS One. 2014; 9(1).
Series:
PEPFAR
Pubmed ID:
24498059
Pubmed Central ID:
PMC3907552
Document Type:
Journal Article
Funding:
MR/K012126/1/Medical Research Council/United Kingdom ; PS024055/PS/NCHHSTP CDC HHS/United States ; PEPFAR/United States
MR/K012126/1/Medical Research Council/United Kingdom ; PS024055/PS/NCHHSTP CDC HHS/United States ; PEPFAR/United States Less -
Place as Subject:
South Africa
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:91876b5e77d7605b2de91d37113384adab622eb71cc5cc78db3035b6ca4f9870
Download URL:
https://stacks.cdc.gov/view/cdc/22511/cdc_22511_DS1.pdf
File Type:

Supporting Files

• 	pone.0087262.t003.jpg	jpeg
  	pone.0087262.t004.gif	gif
  	pone.0087262.t004.jpg	jpeg
  	pone.0087262.g001.gif	gif
  	pone.0087262.g001.jpg	jpeg
  	pone.0087262.nxml	bin
  	pone.0087262.t001.gif	gif
  	pone.0087262.t001.jpg	jpeg
  	pone.0087262.t002.gif	gif
  	pone.0087262.t002.jpg	jpeg
  	pone.0087262.t003.gif	gif

More +