Characterization of Exhaled Breath Condensate (EBC) Non-Exchangeable Hydrogen Functional Types and Lung Function of Wildland Firefighters

Details

• Personal Author:
  Chalbot M-CG ; Kavouras IG ; Nelson J ; Pavicevic Z
• Description:
  Inhalation of smoke is shown to be associated with adverse respiratory outcomes in firefighters. Due to invasiveness of procedures to obtain airways lining fluid, the immediate responses of the target organ (i.e. lung) are secondarily assessed through biomarkers in blood and urine. The objective of this study was to identify changes in metabolic profile of exhaled breath condensate (EBC) and lung function of firefighters exposed to wildfires smoke. A total of 29 subjects were studied over 16 events; 14 of these subjects provided cross-shift EBC samples. The predominant types of non-exchangeable hydrogen in EBC were saturated oxygenated hydrogen, aliphatic alkyl and allylic. Non-exchangeable allylic and oxygenated hydrogen concentrations decreased in post-exposure EBC samples. Longer exposures were correlated with increased abundance of oxidized carbon in ketones, acids and esters. Post-exposure lung function declines (forced expiratory volume in 1 s (FEV1): 0.08 l, forced vital capacity (FVC): 0.07 l, FEV1/FVC: 0.03 l, peak expiratory flow (PEF): 0.39 l s-1) indicated airways inflammation. They were related to exposure intensity (FEV1 and FVC) and exposure duration (PEF). This study showed that EBC characterization of non-exchangeable hydrogen types by NMR may provide insights on EBC molecular compositions in response to smoke inhalation and facilitate targeted analysis to identify specific biomarkers. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Firefighters Fires Lung Occupational Health Respiratory System Safety Wildfires
• Keywords:
  Author Keywords: NMR Spectroscopy Exposure Levels Fire Fighters Inflammation Biomarkers Lung Function Metabolicprofile Pulmonary Function Tests Smoke Inhalation
• ISSN:
  1752-7155
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; New York ; OSHA Region 2 ; OSHA Region 4 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  4
• NIOSHTIC Number:
  nn:20061416
• Citation:
  J Breath Res 2020 Sep; 14(4):046010
• Contact Point Address:
  Ilias G Kavouras, Department of Environmental Health Sciences, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35219, United States of America
• Email:
  ilias.kavouras@sph.cuny.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Alabama at Birmingham
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Breath Research
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e84a94c0ad82316324f1402eddc13958f114547576af253a4d29517e0f440159e5f0ffca405fb2a6dddf43d5e58c17c556ae498e6dabc84784a8fe21379d210
• Download URL:
  https://stacks.cdc.gov/view/cdc/224952/cdc_224952_DS1.pdf
• File Type:
  [PDF - 465.71 KB ]