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Urinary Mutagenicity and Oxidative Status of Wildland Firefighters Working at Prescribed Burns in a Midwestern U.S. Forest



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  • Personal Author:
  • Description:
    Objective: Wildland firefighters (WLFFs) experience repeated exposures to wildland fire smoke (WFS). However, studies about WLFFs remain regionally limited. The objective of this study was to assess the effect of WFS exposure on urinary mutagenicity and cell oxidation among WLFFs who work at prescribed burns in the Midwestern USA. Methods: A total of 120 spot urine samples was collected from 19 firefighters right before (pre-shift), immediately after (post-shift), and the morning (next-morning) following work shifts on prescribed burn days (burn days) and regular workdays (non-burn days). The levels of urinary mutagenicity, 8-isoprostane, malondialdehyde and oxidised guanine species (Ox-GS) were measured. Linear mixed-effect models were used to determine the difference of cross-shift changes in the concentrations of urinary biomarkers. Results: Post-shift levels of creatinine-corrected urinary mutagenicity and 8-isoprostane were non-significantly higher than pre-shift levels (1.16× and 1.64×; p=0.09 and 0.07) on burn days. Creatinine-corrected Ox-GS levels increased significantly in next-morning samples following WFS exposure (1.62×, p=0.03). A significant difference in cross-shift changes between burn and non-burn days was observed in 8-isoprostane (2.64×, p=0.03) and Ox-GS (3.00×, p=0.02). WLFFs who contained the fire (performed holding tasks) had a higher pre-morning to next-morning change in urinary mutagenicity compared with those who were lighting fires during the prescribed burns (1.56×, p=0.03). Conclusions: Compared with the other regions, WLFFs who worked in Midwestern forests had an elevated urinary mutagenicity and systemic oxidative changes associated with WFS exposure at prescribed burns. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1351-0711
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    8 pdf pages
  • NIOSHTIC Number:
    nn:20061401
  • Citation:
    Occup Environ Med 2021 May; 78(5):315-322
  • Contact Point Address:
    Dr. Olorunfemi Adetona, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
  • Email:
    adetona.1@osu.edu
  • Federal Fiscal Year:
    2021
  • Performing Organization:
    University of Michigan, Ann Arbor
  • Peer Reviewed:
    True
  • Start Date:
    20050701
  • Source Full Name:
    Occupational and Environmental Medicine
  • End Date:
    20280630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:ff90c9e708bbafed5b0cf97aa2ea50a6d302cc9b79b2eb49c47aadc44c79fe106e65a2efe59704af65c15eb05c3967e915302b335a0a9389b96819ec54d5d6f8
  • Download URL:
  • File Type:
    Filetype[PDF - 290.56 KB ]
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