Measuring Acute Pulmonary Responses to Occupational Wildland Fire Smoke Exposure Using Exhaled Breath Condensate

Details

• Personal Author:
  Adetona A ; Adetona O ; Naeher L ; Song C(C) ; Wu C-M
• Description:
  Wildland firefighters are directly exposed to elevated levels of wildland fire (WF) smoke. Although studies demonstrate WF smoke exposure is associated with lung function changes, few studies that use invasive sample collection methods have been conducted to investigate underlying biochemical changes. These methods are also either unrepresentative of the deeper airways or capable of inducing inflammation. In the present study, levels of biomarkers of oxidative stress (8-isoprostane) and pro-inflammatory response (interleukin-6 [IL-6], interleukin-8 [IL-8], C-reactive protein [CRP], and soluble intercellular adhesion molecule-1 [sICAM-1]) were determined in exhaled breath condensate (EBC) samples that were collected from firefighters before, after, and next morning following prescribed burn and regular work shifts. Results show only a marginal cross-shift increase in 8-isoprostane on burn days (.05

• Subjects:
  Biomarkers Firefighters Fires Lung Occupational Health Respiratory System Safety Wildfires
• Keywords:
  Author Keywords: Acute Pulmonary Response Exhaled Breath Condensate Fire Fighters Inflammation Lung Function Oxidative Stress Pulmonary Function Tests Smoke Inhalation Wildland Firefighter Wildland Fire Smoke
• ISSN:
  1933-8244
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  65-69
• Volume:
  75
• Issue:
  2
• NIOSHTIC Number:
  nn:20058348
• Citation:
  Arch Environ Occup Health 2020 Feb; 75(2):65-69
• Contact Point Address:
  Olorunfemi Adetona, Division of Environmental Health Sciences, College of Public Health, The Ohio State University, 1841 Neil Avenue, Columbus, OH 43210, USA
• Email:
  adetona.1@osu.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Alabama at Birmingham
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Archives of Environmental & Occupational Health
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:436159b3713f22cdb8df62afd9d0ab071453b2f37a543adcc6f614a36fd4c508ca3d7029c4de4fb8088048cecc25f9d8dceaceb6156caec6e11d80956b1f1143
• Download URL:
  https://stacks.cdc.gov/view/cdc/221466/cdc_221466_DS1.pdf
• File Type:
  [PDF - 673.03 KB ]