Circadian Effect of ACTH 1–17 on Mitotic Index of the Corneal Epithelium of BALB/C Mice

Details

• Personal Author:
  Halberg F ; Pauly JE ; Scheving LE ; Tsai TH
• Description:
  The objective was to determine the effect of ACTH 1-17, an adrenocorticotropin analogue, on the mitotic index in the corneal epithelium of mice standardized in 12 hr of light alternating with 12 hr darkness. A question asked was whether the time of administration along the 24-hr time scale influenced any response found. The findings showed that ACTH 1-17 could, depending upon when it was administered, bring about a statistically significant decrease, an increase or even no such change in the mitotic index. The greatest responses found were increases, especially when ACTH 1-17 was administered during the dark span. Also the time after injection when the responses occurred varied. The greatest response recorded was at 12 hr after injection when ACTH 1-17 was given at 2 hr into the dark with a 641% and a 718% increase with a low (0.02 IU/kg) and a higher (20 IU/kg) dose, respectively. A 3-way analysis of variance supported the conclusion that the kind-of-treatment, time-of-treatment and treatment-to-kill interval (sampling time) are important factors when determining any response to ACTH 1-17 on the mitotic index. [Description provided by NIOSH]
• Subjects:
  Animals Circadian Rhythm Lighting Occupational Health Safety
• Keywords:
  ACTH 1-17 Animal Studies Author Keywords: Cornea Biological Rhythms Circadian Rhythm Circadian Rhythms Hormone Activity Mitotic Index Peptides Placebo
• ISSN:
  0196-9781
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Minnesota ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  183-190
• Volume:
  4
• Issue:
  2
• NIOSHTIC Number:
  nn:20060824
• Citation:
  Peptides 1983 Mar-Apr; 4(2):183-190
• Contact Point Address:
  Dr. L. E. Scheving, University of Arkansas for Medical Sciences, Department of Anatomy, Slot 510, 4301 West Markham, Little Rock, AR 72205
• Federal Fiscal Year:
  1983
• Performing Organization:
  University of Arkansas Med Scis Ltl Rock, Little Rock, Arkansas
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  Peptides
• End Date:
  19880301
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c06d6a2fdba0bf8892bb394c33e8d1f810879f391969f1638670ec5493410bbd0c74341f54516aac496bca102d929afb7d22bc2b2d9a2f9949e1000595ea6bd9
• Download URL:
  https://stacks.cdc.gov/view/cdc/224624/cdc_224624_DS1.pdf
• File Type:
  [PDF - 732.47 KB ]