Effect of ACTH 1–17 at Different Circadian Stages on [3H]TdR Incorporation into DNA

Details

• Personal Author:
  Halberg F ; Pauly JE ; Scheving LE ; Tsai TH
• Description:
  The objective was to determine the effect of adrenocorticotropin (ACTH 1-17) on the incorporation of 3HTdR into DNA (DNA synthesis) in the tongue, esophagus and stomach of CD2F1 mice standardized to 12 hours of light alternating with 12 hours of darkness. A question asked was whether the time of administration along the 24-hour time scale influenced any response found. The response was complex as ACTH 1-17 was capable of bringing about statistically significant increases in the incorporation of 3HTdR into DNA at certain times, decreases at other times, or no response at still another time. In general the most marked effects of 20 IU/kg of ACTH 1-17 when compared to controls, was to decrease DNA synthesis of as much as 60% 4 hours after administration at the end of the dark or beginning of the light span. A 2- and 3-way analysis of variance supported the conclusion that the kind-of-treatment, time-of-treatment and the interval-to-kill (Sampling time) as well as their interactions are important factors when determining any response of ACTH 1-17 or placebo. Description provided by NIOSH
• Subjects:
  • Animals
  • Circadian Rhythm
  • Occupational Health
  • Safety
• Keywords:
  • Peptides
  • Animal studies
  • DNA
  • Deoxyribonucleic acids
  • Biological rhythms
  • Circadian rhythms
  • Author Keywords: ACTH 1-17
  • DNA
  • Circadian
  • Rhythm
  More +
• ISSN:
  0196-9781
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Minnesota ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  3
• NIOSHTIC Number:
  nn:20060640
• Citation:
  Peptides 1984 May-Jun; 5(3):507-518
• Contact Point Address:
  Dr. L. E. Scheving, University of Arkansas for Medical Sciences, Department of Anatomy, Slot 510, 4301 West Markham, Little Rock, AR 72205
• Federal Fiscal Year:
  1984
• Performing Organization:
  University of Arkansas Med Scis Ltl Rock, Little Rock, Arkansas
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  Peptides
• End Date:
  19880301
• Download URL:
  https://stacks.cdc.gov/view/cdc/224490/cdc_224490_DS1.pdf
• File Type:
  [PDF - 962.60 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc8e4665e2e7d08883cc95f1d6174e01a923ddf29a6b7b0b742770d066a3919130730620617258213075d0ed6da503d4c037406979406b0c2ea8be7eda8fe0a2