Effect of ACTH 1–17 at Different Circadian Stages on [3H]TdR Incorporation into DNA

Details

• Personal Author:
  Halberg F ; Pauly JE ; Scheving LE ; Tsai TH
• Description:
  The objective was to determine the effect of adrenocorticotropin (ACTH 1-17) on the incorporation of [3H]TdR into DNA (DNA synthesis) in the tongue, esophagus and stomach of CD2F1 mice standardized to 12 hours of light alternating with 12 hours of darkness. A question asked was whether the time of administration along the 24-hour time scale influenced any response found. The response was complex as ACTH 1-17 was capable of bringing about statistically significant increases in the incorporation of [3H]TdR into DNA at certain times, decreases at other times, or no response at still another time. In general the most marked effects of 20 IU/kg of ACTH 1-17 when compared to controls, was to decrease DNA synthesis of as much as 60% 4 hours after administration at the end of the dark or beginning of the light span. A 2- and 3-way analysis of variance supported the conclusion that the kind-of-treatment, time-of-treatment and the interval-to-kill (Sampling time) as well as their interactions are important factors when determining any response of ACTH 1-17 or placebo. [Description provided by NIOSH]
• Subjects:
  Animals Circadian Rhythm Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: ACTH 1-17 Biological Rhythms Circadian Circadian Rhythms Deoxyribonucleic Acids DNA Esophagus Peptides Placebo Rhythm Stomach Tongue

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• ISSN:
  0196-9781
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Minnesota ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  3
• NIOSHTIC Number:
  nn:20060640
• Citation:
  Peptides 1984 May-Jun; 5(3):507-518
• Contact Point Address:
  Dr. L. E. Scheving, University of Arkansas for Medical Sciences, Department of Anatomy, Slot 510, 4301 West Markham, Little Rock, AR 72205
• Federal Fiscal Year:
  1984
• Performing Organization:
  University of Arkansas Med Scis Ltl Rock, Little Rock, Arkansas
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  Peptides
• End Date:
  19880301
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc8e4665e2e7d08883cc95f1d6174e01a923ddf29a6b7b0b742770d066a3919130730620617258213075d0ed6da503d4c037406979406b0c2ea8be7eda8fe0a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/224490/cdc_224490_DS1.pdf
• File Type:
  [PDF - 962.60 KB ]