Circadian-Stage Dependent ACTH 1–17 Effect on DNA Synthesis in Murine Duodenum, Colon and Rectum

Details

• Personal Author:
  Halberg F ; Pauly JE ; Scheving LE ; Tsai TH
• Description:
  The objective was to determine the effect of adrenocorticotropin (ACTH 1-17) on the incorporation of [3H]TdR into DNA (DNA synthesis) in the duodenum, colon and rectum of CD2F, mice standardised to 12hr of light alternating with 12hr of darkness. A question asked was whether the difference in times of administration along the 24 -hr time scale influenced any response found. The response was complex as ACTH 1-17 was capable of bringing about statistically significant increases in the incorporation of [3H]TdR into DNA at certain times, decreases at other times, or no response at still another time. A generalization that can be made from all these tissues is that ACTH 1-17 had a greater influence in bringing about a decrease in DNA synthesis when it was administered around the time of transition from dark to light. A similar finding was made earlier for the ACTH 1-17 effect upon the tongue, esophagus and stomach. A 2- and 3-way analysis of variance supports our conclusion that the kind-of-treatment, time-of-treatment and the interval-to-kill (Sampling time) as well as their interactions are important factors when determining any response of ACTH 1-17 or placebo. [Description provided by NIOSH]
• Subjects:
  Animals Circadian Rhythm Enzymes Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: CTH 1-17 Biological Rhythms Circadian Circadian Rhythms Colon Deoxyribonucleic Acids Digestive System DNA Duodenum Hormone Activity Physiological Effects Placebo Rectum Rhythm

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• ISSN:
  0742-0528
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Minnesota ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  251-266
• Volume:
  1
• Issue:
  4
• NIOSHTIC Number:
  nn:20060686
• Citation:
  Chronobiol Int 1984 Oct; 1(4):251-266
• Contact Point Address:
  Dr. L. E. Scheving, University of Arkansas for Medical Sciences, Department of Anatomy, Slot 510, 4301 West Markham, Little Rock, AR 72205, U.S.A.
• Federal Fiscal Year:
  1985
• Performing Organization:
  University of Arkansas Med Scis Ltl Rock, Little Rock, Arkansas
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  Chronobiology International
• End Date:
  19880301
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aa11b33d287e8487e422ff4cfd84f1bdcdd80bf9a4133c74d05e9193d745a2f6b3a6ffd3691f370c84adfdbf57a752486aca41b12712ac3dea8992341eeb9097
• Download URL:
  https://stacks.cdc.gov/view/cdc/224525/cdc_224525_DS1.pdf
• File Type:
  [PDF - 479.88 KB ]