Neurotoxic Properties of Musk Ambrette

Details

• Personal Author:
  Bischoff-Fenton MC ; Ford RA ; Moreno OM ; Opdyke DL ; Spencer PS
• Description:
  Musk ambrette (2,6-dinitro-3-methoxy-4-tert-butyltoluene), a nitro-musk compound widely used as a fixative in fragrance formulations and found to a lesser degree in flavor compositions, produces hindlimb weakness when administered in the diet or applied to skin of rats for periods up to 12 weeks. Underlying neuropathologic changes consist of primary demyelination and distal axonal degeneration in selected regions of the central and peripheral nervous system. Murine neurological disease induced by musk ambrette occurs at doses well above estimated maximum daily human exposure. Lifetime experimental neurotoxicology studies using lower concentrations of musk ambrette for prolonged periods would be needed for the estimation of human risk. [Description provided by NIOSH]
• Subjects:
  • Animals
  • Flavoring Agents
  • Nervous System
  • Occupational Health
  • Safety
  • Skin
• Keywords:
  • Animal studies
  • Neuropathy
  • Neurological system
  • Neurotoxic effects
  • Neurotoxins
  • Exposure assessment
  • Skin exposure
  • Neuropathology
  • Flavorings
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; New York ; OSHA Region 2 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  75
• Issue:
  3
• NIOSHTIC Number:
  nn:20060603
• Citation:
  Toxicol Appl Pharmacol 1984 Sep; 75(3):571-575
• Federal Fiscal Year:
  1984
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19800501
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19890430
• Download URL:
  https://stacks.cdc.gov/view/cdc/224462/cdc_224462_DS1.pdf
• File Type:
  [PDF - 794.36 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:48950a238697463ca020868ac9473a4210a5fd870d4655a47bccdae5dd61654762c3b5c9c2575fa343879032ad12bcdd695e0403260670f0639bf1126aefc17c