Interferon Enhancement of HLA-DR Antigen Expression on Epidermal Langerhans Cells

Details

• Personal Author:
  Berman B ; Duncan MR ; Palladino M ; Smith B ; Ziboh VA
• Description:
  Langerhans cells (LCs) are dendritic epidermal cells whose ability to function as accessory/stimulatory cells in initiating the immune response is, like that of macrophages, dependent on the expression of class II major histocompatibility antigens. In normal human skin approximately 50% of LCs identified by cell surface T6 antigenicity also express HLA-DR histocompability determinants. We report here that recombinant DNA-derived human interferon (IFN)-gamma, but not IFN- alpha2, induces the expression of HLA-DR antigens by the population of human epidermal LCs on which such antigens normally are not detected. IFN-gamma effectively induced HLA-DR on both neonatal and adult epidermal LCs and such induction was blocked by neutralization with a murine monoclonal antibody to IFN- gamma. IFN-gamma induction of LC HLA-DR expression is inhibited by prostaglandin E2(PGE2) and is mimicked by the presence of fatty acid cyclooxygenase inhibitors, known to reduce PGE2 production. These results suggest that IFN-gamma may play a role in regulating skin-associated immune responses through enhanced expression of HLA-DR antigens on LCs and that such enhancement may be mediated by alterations in arachidonic acid metabolism. [Description provided by NIOSH]
• Subjects:
  Antigens Immune System Occupational Health Safety Skin
• Keywords:
  Cellular Effects Dermal Exposures Dermatology Immune Reaction Immune System Skin Tests
• ISSN:
  0022-202X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  54-58
• Volume:
  84
• Issue:
  1
• NIOSHTIC Number:
  nn:20060571
• Citation:
  J Invest Dermatol 1985 Jan; 84(1):54-58
• Contact Point Address:
  Brian Berman, M.D., Dermatology Service (190), V. A. Medical Center, 150 Muir Road, Martinez, California 94553
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Investigative Dermatology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:63c07fbbca6a94918c5c1cf787550878064711d4830c9c38fa9c17b1bcd7806379bf3527fa154f08c8566281cee1d8391c9f8d8086527450f156a8fed5ee03d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/224435/cdc_224435_DS1.pdf
• File Type:
  [PDF - 2.27 MB ]