U.S. flag An official website of the United States government.
Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

i

Modulation of Expression of Epidermal Langerhans Cell Properties Following In Situ Exposure to Glucocorticosteroids



Details

  • Personal Author:
  • Description:
    Langerhans cells (LC) have been implicated as antigen-presenting and target cells in contact allergic, cell-mediated reactions. We have examined the effects in guinea pigs, rats, and humans of in situ (epicutaneous) exposure to glucocorticosteroids (GCS) on the expression of epidermal LC markers. Reductions in the number of Fc-rosetting, C3b-rosetting, and immune-associated (Ia) antigen-bearing LC occurred in a dose-related fashion, with the degree of such reductions dependent upon the specific GCS employed. These reductions were determined to be reversible following cessation of exposure to GCS. T6 antigenicity, another cell surface marker of human LC, was little affected by GCS exposure. Simultaneous immunofluorescent staining for T6 and Ia antigenicity within human epidermis of amcinonide-treated skin detected reduced numbers of T6+/Ia+ cells with a concomittant increase in T6+/Ia- cells. The data presented suggest a selective reduction in the expression of immunologically important receptors and antigens by LC which may be involved in steroid-responsive contact allergic reactions. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0022-202X
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    168-171
  • Volume:
    80
  • Issue:
    3
  • NIOSHTIC Number:
    nn:20060823
  • Citation:
    J Invest Dermatol 1983 Mar; 80(3):168-171
  • Contact Point Address:
    Dr. Brian Berman, Dermatology Service, V.A. Medical Center, 150 Muir Road, Martinez, California 94553
  • Federal Fiscal Year:
    1983
  • Peer Reviewed:
    True
  • Source Full Name:
    Journal of Investigative Dermatology
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:4635d521e9cbe63b840a1c50d35f94a799f08301fe47e3ac383d8a03921325c69466b725b2962b97fba3c4f13efdfa14097bef3422265fbcde5c9b6d5aff7f35
  • Download URL:
  • File Type:
    Filetype[PDF - 3.19 MB ]
PREVIOUS
ON THIS PAGE
Details
CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
BACK TO TOP