Anti-Inflammatory Properties of an Oxidized Sterol

Details

• Personal Author:
  Gaspari AA ; Rietschel RL
• Description:
  A polar photoproduct of cholesterol oxidation, 7-ketocholesterol, was able to inhibit in a dose-dependent manner the mouse ear-swelling response to irritants such as croton oil or cantharidin. Its anti-inflammatory properties were much less than equivalent concentrations of hydrocortisone, but the oxidized sterol did not induce any systemic effects (as measured by thymolytic activity), as did topical hydrocortisone. It is concluded that 7-ketocholesterol has weak anti-inflammatory activity, and its mode of action may be different from that of glucocorticoids. [Description provided by NIOSH]
• Subjects:
  Immune System Occupational Health Safety Skin
• Keywords:
  Dermal Exposures Dermatology Immune Reaction Immune System Skin Irritants Skin Sensitivity
• ISSN:
  0022-202X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  126-129
• Volume:
  84
• Issue:
  2
• NIOSHTIC Number:
  nn:20060518
• Citation:
  J Invest Dermatol 1985 Feb; 84(2):126-129
• Contact Point Address:
  Anthony A. Gaspari, M.D., Department of Dermatology, 207 Woodruff Memorial Building, Emory University School of Medicine, Atlanta, Georgia 30322
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Investigative Dermatology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0892c3c2b104d27f627dc65bd208f88dfc8b90b9c443a972759bd24458cc9efa99ec266f916bc759f58409d2d62cd6d6e5db54d1aff61c3b857e25b53c34ecf8
• Download URL:
  https://stacks.cdc.gov/view/cdc/224390/cdc_224390_DS1.pdf
• File Type:
  [PDF - 1.51 MB ]