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Pharmacokinetic Interpretation of the Plasma Levels of Clonidine Following Transdermal Delivery



Details

  • Personal Author:
  • Description:
    The use of transdermal drug delivery to elicit a sustained systemic effect is a subject of considerable current interest. The scopolamine and nitroglycerin therapeutic systems have recently been joined by a transdermal device containing clonidine, a potent antihypertensive agent. Clonidine meets many of the criteria necessary for a drug to be delivered successfully via the skin: it is highly efficacious at low doses, it has both reasonable oil and water solubilities, and it possesses a well-balanced lipid-aqueous phase partition coefficient. The purpose of this communication is to show that, through the use of a biophysically-based model of percutaneous absorption, the physicochemical properties of the drug may be related to the design of the transdermal delivery system (i.e., its release characteristics) to predict plasma levels following topical administration of the agent. The approach is illustrated using clonidine for which pharmacokinetic data following transdermal delivery have recently been published. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0022-3549
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    74
  • Issue:
    9
  • NIOSHTIC Number:
    nn:20060467
  • Citation:
    J Pharm Sci 1985 Sep; 74(9):1016-1018
  • Contact Point Address:
    Richard H. Guy, Departments of Pharmacy and Pharmaceutical Chemistry School of Pharmacy University of California San Francisco, CA 94143
  • Federal Fiscal Year:
    1985
  • Performing Organization:
    University of California San Francisco, San Francisco, California
  • Peer Reviewed:
    False
  • Start Date:
    19840928
  • Source Full Name:
    Journal of Pharmaceutical Sciences
  • End Date:
    19871231
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:ac074ff41203b0d1f4d8af893f309b7518d415ea68e395be35536735febd5a05de76684db850deeddb2225745730e192b258f23374e09da114a4fc6c2d0a3669
  • Download URL:
  • File Type:
    Filetype[PDF - 294.55 KB ]
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