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Drug Delivery to Local Subcutaneous Structures Following Topical Administration



Details

  • Personal Author:
  • Description:
    This article brings together a collection of results and observations which demonstrate the achievement of significant drug delivery to local subcutaneous structures following topical administration. It is probably no exaggeration to say that the concept of using the transdermal route to advantageously reach lower tissue, such as the muscle beneath the subcutaneous fat, goes directly against conventional thought. Indeed, the cutaneous microvasculature has long been offered as an excellent example of a classical "sink" phenomenon; that is, following penetration through the stratum corneum, epidermis, and upper dermis, it has been held that the permeating species will then pass into one of the small blood vessels forming the microcapillary network and hence be systemically diluted in the circulatory system. The argument seems totally reasonable: the stratum corneum is an excellent barrier to the passage into the body of many substances that contact with the skin. Thus, in the large majority of cases, drug arrival beneath the stratum corneum is slow such that the concentration of material at this point is invariably very much less than that present on the skin surface. These conditions are precisely those implicit in a "sink" situation and, coupled with the extensive dermal capillary matrix, it is not surprising that further penetration into the tissue has been considered unlikely. On closer perusal of the literature, however, it becomes apparent that a small but significant number of reports exist which show that deeper penetration can take place and that subcutaneous drug levels can be achieved following topical application which cannot be reached after parenteral or oral administration of the active agent. This brief review gathers the results available in the (admittedly) diverse sources to reanalyze conventional thought and to stimulate inquiry into this important aspect of drug input via the skin. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0022-3549
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    72
  • Issue:
    12
  • NIOSHTIC Number:
    nn:20060691
  • Citation:
    J Pharm Sci 1983 Dec; 72(12):1375-1380
  • Contact Point Address:
    Richard H. Guy, School of Pharmacy and Department of Dermatology, School of Medicine, University of California-San Francisco, San Francisco, CA 94143
  • Federal Fiscal Year:
    1984
  • Peer Reviewed:
    True
  • Source Full Name:
    Journal of Pharmaceutical Sciences
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:518098322ccc9145959b2703571c5036a5b68559699c3ff7205ca590fbd1626290bed8d0cc8dcc89e16c9aeaa970618fbca4f68187b8b9c7a47f7dc794b706f1
  • Download URL:
  • File Type:
    Filetype[PDF - 659.87 KB ]
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