Epidemiologic Evidence on the Relationship Between Environmental Endocrine Disruptors and Male Reproductive and Developmental Health

Details

• Personal Author:
  Barthold JS ; Hauser R ; Meeker JD
• Description:
  There is scientific, governmental, and public concern over the potential adverse human health risks of exposure to environmental endocrine-disrupting chemicals (eEDCs). Human health endpoints of concern include, among others, (i) disrupted reproductive function, manifest as infertility or early pregnancy loss, (ii) altered fetal development, manifest as urogenital tract abnormalities in male newborns, including hypospadias and cryptorchidism, (iii) altered thyroid function, and (iv) increased risk of reproductive cancers including breast in women and testicular and prostate in men. Other endpoints that have also been studied include increased risk of endometriosis and altered birth sex ratios. Given the wide range of potential health endpoints, it would not be possible to synthesize the existing epidemiologic evidence in a single chapter. Therefore, we made the decision to focus on a subset of literature, specifically male reproductive and developmental health endpoints, for which there is some human epidemiologic evidence. In addition, because it has been hypothesized that several of the male reproductive and developmental endpoints may be linked through a common casual pathway, testicular dysgenesis syndrome (TDS) (1), which may include exposure to environmental endocrine-disrupting chemicals (eEDCs), we welcomed the opportunity to explore their relationship with eEDCs in depth. [Description provided by NIOSH]
• Subjects:
  Endocrine System Environmental Exposure Epidemiology Men Neoplasms Occupational Health Risk Assessment Risk Factors Safety Urogenital Diseases Urogenital System

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• Keywords:
  Cancer Chemicals Endocrine Disruptors Exposure Levels Health Effects Humans Reproductive Effects Reproductive Hazards Reproductive Health Reproductive System Disorders Risk Factors Testes Testicular Cancer

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• ISBN:
  9781588298300
• Publisher:
  Humana Press
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  225-252
• NIOSHTIC Number:
  nn:20060390
• Citation:
  Endocrine-disrupting chemicals: from basic research to clinical practice (Contemporary endocrinology). Gore AC, Conn PM eds. Totowa, NJ: Humana Press, 2007 Jun; :225-252
• Editor(s):
  Gore AC; Conn PM
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Endocrine-disrupting chemicals: from basic research to clinical practice (Contemporary endocrinology)
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:702651141b04a9b47765210a897b0eaf22179b517a695ec3eab7cda99752b00062cd51cd0f9a608a4104c81052f5dac7d8d3f428ca7e6e3ce33f163f9a5d7d21
• Download URL:
  https://stacks.cdc.gov/view/cdc/224317/cdc_224317_DS1.pdf
• File Type:
  [PDF - 1.14 MB ]