Transgenerational Work Exposures, EDCs and Male Fertility

Details

• Personal Author:
  Meyer, J. D.
• Description:
  Male infertility and subfertility accounts for roughly half of the 10-15% prevalence of overall failure to conceive a child. This work is one of the first to examine the role of occupational exposures sustained by parents of male subjects in reduced fertility or susceptibility to insult from occupational exposures in the subsequent generation. Using a unique dataset of male reproductive parameters and male-maternal questionnaire data, we modeled effects of work exposures of two generations on men's semen and hormonal parameters. Lower sperm concentration and motility, contrasted with office workers, were seen in some equipment installation, maintenance, and repair occupations. A higher prevalence of exposure to lead, and, to a lesser extent, to pesticides/herbicides and to solvents was seen in occupations with lower mean sperm concentrations. Lower sperm concentration was seen in participants who noted work exposure to lead that went on for 3 months or longer compared with those not exposed, This decrement in semen quality was increased further in those who also had lead exposure outside of work. Depression of semen quality may be occurring at work even in demonstrably fertile men, particularly in jobs exposed to lead. These results may help to identify occupations where additional consideration of protective measures against exposures with male reproductive toxicity might be warranted. Additionally, we have found preliminary evidence for decreased sperm quality in men whose mothers worked in jobs that likely exposed them to endocrine-disrupting chemicals (EDCs). Total sperm counts were decreased in men whose mothers were probably exposed at work contrasted with those born of unexposed mothers, while probable paternal work with EDCs did not lead to a similar reduction. Further analyses are forthcoming on this finding. The findings of this study will help inform efforts to reduce work hazards and exposures in both fertile men and women and cross-generationally. [Description provided by NIOSH]
• Subjects:
  Endocrine System Environmental Exposure Insecticides Lead Men Occupational Health Risk Assessment Risk Factors Safety Solvents Surveys And Questionnaires Urogenital Diseases Urogenital System Women Workplace

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• Keywords:
  Chemicals Endocrine Function Endocrine System Exposure Levels Health Effects Hormones Humans Infertility Models Pesticides Protective Measures Questionnaires Reproductive Effects Reproductive Hazards Reproductive System Disorders Risk Factors Spermatozoa Statistical Analysis Work Environment Workers

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• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-7
• NIOSHTIC Number:
  nn:20065801
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R03-OH-011540, 2022 Feb; :1-7
• Contact Point Address:
  John D Meyer MD MPH, Professor, Dept of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY 10029
• Email:
  john.meyer@mssm.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2022
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20180930
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20200929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:404fd6d16acefa60cae0260e96667dabcf4bdc9feebfbc3c01180e3ec498f0ac84e7255a3e91cb7aeff971c854131bba6ae0634e9dc7ec974bc770d426f7d879
• Download URL:
  https://stacks.cdc.gov/view/cdc/219125/cdc_219125_DS1.pdf
• File Type:
  [PDF - 184.30 KB ]