Are Nanoparticles Potential Male Reproductive Toxicants? A Literature Review

Details

• Personal Author:
  McAuliffe ME ; Perry MJ
• Description:
  The rapid advancement of nanotechnology has prompted the need to investigate the health effects of nanoparticles and nanomaterials. The current focus of health and safety investigations has targeted routes of exposure and potential deposition, translocation, and adverse effects in primary and major secondary target organs. Few studies have looked at deposition in reproductive organs, and even fewer have assessed potential adverse effects on germline cells. This review summarizes the current published research on deposition/translocation of nanoparticles to the testes and male germline cells, and the potential cytotoxic effects. Six research articles were identified. Three articles pertained to deposition/ translocation of nanoparticles in the testes, two pertained to cytotoxicity of nanoparticles on male germline cells, and one study assessed deposition and bioaccumulation of nanoparticles in the testes, and potential for adverse reproductive outcomes in successive offspring. While research into the potential reproductive toxicity of nanoparticles is still in its infancy, the identified research suggests that nanoparticles cross the blood testes barrier and deposit in the testes, and that there is potential for adverse effects on sperm cells. Suggestions for future research strategies are outlined. [Description provided by NIOSH]
• Subjects:
  Cytotoxins Environmental Exposure Hazardous Substances Men Occupational Health Risk Assessment Risk Factors Safety Urogenital Diseases Urogenital System
• Keywords:
  Author Keywords: Nanoparticles Cytotoxic Effects Exposure Levels Germline Cells Health Effects Humans Nanomaterials Nanoparticles Nanotechnology Reproductive Effects Reproductive System Reproductive System Disorders Reproductive Toxicity Risk Factors Sperm Testes Toxins

  More +
• ISSN:
  1743-5390
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  204-210
• Volume:
  1
• Issue:
  3
• NIOSHTIC Number:
  nn:20057644
• Citation:
  Nanotoxicology 2007 Sep; 1(3):204-210
• Contact Point Address:
  Melissa J. Perry, ScD, Environmental and Occupational Medicine and Epidemiology Program, Harvard School of Public Health, 665 Huntington Ave, Bldg I-1418A, Boston, MA 02115
• Email:
  mperry@hsph.harvard.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Nanotoxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:10bfe3d60678f13b63315b3aa944f4adf0602406e0b891adf95852fa2b92b969ce4126c3da748e51a38818a2ace6cb8467f750720be84d0ebfcecf026b94fab1
• Download URL:
  https://stacks.cdc.gov/view/cdc/214916/cdc_214916_DS1.pdf
• File Type:
  [PDF - 254.42 KB ]