Epidemiological Studies on the Relationship Between Semen Quality and Environmental Chemicals: Historic and Contemporary Compounds

Details

• Personal Author:
  Hauser R ; Meeker JD
• Description:
  Recent reports of downward trends in semen quality and increased rates of developmental urogenital tract anomalies and testicular cancer have raised both scientific and public concern about the potential risk of environmental chemicals to male reproductive health. Of particular concern is whether some contemporary use environmental chemicals alter semen quality. Semen quality refers to both conventional measures, such as sperm concentration, motility and morphology, as well as sperm DNA integrity as assessed by bioassays. Specific toxicants of interest include phthalates and pesticides (primarily insecticides and herbicides), as well as polychlorinated biphenyls (PCBs). The human data on the relationship of semen quality with phthalate and pesticide exposure are limited and does not currently allow for a definitive conclusion on whether adult exposure, at background environmental levels, alters semen quality. However, the epidemiologic data support an inverse association of PCBs with reduced semen quality, specifically reduced sperm motility. The associations found were generally consistent across studies despite a range of PCB levels. In addition to the chemicals discussed in detail, there are additional classes of chemicals that require further study as to their relation with human semen quality. These chemicals include alkylphenols, such as 4-nonylphenol, bisphenol A and the fluorinated organic compounds. [Description provided by NIOSH]
• Subjects:
  Biological Assay Chemistry Epidemiology Herbicides Insecticides Men Occupational Health Phthalic Acids Polychlorinated Biphenyls Safety Urogenital Diseases Urogenital System

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• Keywords:
  Alkylphenols Author Keywords: Sperm Motility Bioassays Bisphenol A Chemical Properties Chemical Reactions Chemicals Deoxyribonucleic Acids DNA Humans Morphology Motile Sperm PCBs Pesticides Phthalates Polychlorinated Biphenyls Reproduction Reproductive Effects Reproductive System Reproductive System Disorders Semen Quality Seminal Plasma Spermatozoa Sperm Concentration

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• ISBN:
  9781402048289
• ISSN:
  1382-3124
• Publisher:
  Springer
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  23-56
• NIOSHTIC Number:
  nn:20060379
• Citation:
  Reproductive health and the environment. Nicolopoulou-Stamati P, Hens L, Howard CV, eds. Netherlands; Springer, 2007 Jan; :23-56
• Contact Point Address:
  R. Hauser, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; 2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Editor(s):
  Nicolopoulou-Stamati P; Hens L; Howard CV
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Reproductive health and the environment
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0b8f81a49c4299f30018af976d282b05a1f46daaaadb3975bafadcdcea705b0ed7b41eb182ff1172250dd4a1d719e9c30560ccf610df929344524da099ebdbd
• Download URL:
  https://stacks.cdc.gov/view/cdc/224313/cdc_224313_DS1.pdf
• File Type:
  [PDF - 2.36 MB ]