Concentration and Chemical Status of Arsenic in the Blood of Pregnant Hamsters During Critical Embryogenesis: 1. Subchronic Exposure to Arsenate Utilizing Constant Rate Administration

Details

• Personal Author:
  Ferm VH ; Hanlon DP
• Description:
  We have determined the concentration, availability, and chemical status of radiolabeled arsenic in the blood of pregnant hamsters at the beginning (morning of Day 8) and the end (morning of Day 9) of the critical period of embryogenesis. Hamster dams were exposed to teratogenic doses of arsenate by means of osmotic minipumps implanted on the morning of Day 6 of the gestation period. Whole blood arsenic concentrations were the same for 48 and 72 hr postimplant. The arsenic concentration of plasma equaled that of red cells. Plasma arsenic was not bound to macromolecules and had the same chemical status 48 and 72 hr postimplant. Arsenate was the dominant form (67% of the total). However, the presence of dimethylarsinic acid and arsenite indicates that the pentavalent species was metabolized. Red cell arsenic was bound to macromolecules in the cell sap. Seventy percent of red cell sap arsenic was dialyzable 48 hr postimplant, but only 56% 72 hr postimplant. Arsenate was the dominant dialyzable red cell species on Day 8 and arsenite was the major dialyzable form on Day 9. Our findings demonstrate a relationship between the maternal blood concentration and chemical status of arsenic and the presence of malformations resulting from a constant rate exposure of pregnant hamsters to arsenate via the osmotic minipump. [Description provided by NIOSH]
• Subjects:
  Animals Arsenic Inorganic Chemicals Occupational Health Pregnancy Safety Teratogenesis
• Keywords:
  Animal Studies Arsenates Embryopathology Prenatal Exposure Teratogens Toxic Effects
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Hampshire ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  372-379
• Volume:
  40
• Issue:
  2
• NIOSHTIC Number:
  nn:20060281
• Citation:
  Environ Res 1986 Aug; 40(2):372-379
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5959ce572a5e55efaef9234443a9ac2bb8e9aa34f3cb114d46087dee3c5ee710831a782cd0565342084173d52a34491f59486542f954ec698809ed9d23c2dd27
• Download URL:
  https://stacks.cdc.gov/view/cdc/224231/cdc_224231_DS1.pdf
• File Type:
  [PDF - 526.90 KB ]