Nervous System Damage Precedes Immune System Involvement in Male Mice Exposed to Pb

Details

• Personal Author:
  El-Fawal HA ; Snyder CA ; Waterman S
• Description:
  Previously we presented evidence that Pb may provoke an immune response against nervous system (NS) structures. However, it is not known whether Pb-induced neural damage must precede the immune response. To resolve this question, male and female CBNJ mice were exposed to 820 ppm Pb in the drinking water. Endpoints included: serum autoantibody (AuAb) titers to nervous system proteins (NSP): neurofilaments (NF), glial fibrillary acidic protein (GFAP) and myelin basic protein as well as interleukin 2 and 6 (IL-2,IL-6) levels from supernatants of lectin-stimulated splenocytes. GFAP was used as a cerebellum of male mice at 5d but recovered to baseline afterward. In males, serum AuAbs to NSP were mostly directed against the NFs and peaked predominately at 10d. These early AuAb changes accompanied IL-6 elevations (10d), followed by IL-2 elevations (28d). Analogous effects were not seen in female mice. These results suggest that NS damage, as indicated by elevated GFAP levels, precedes AuAb production in male mice suggesting that Pb-induced neural damage precedes the immune response. This study also confirms that males are more sensitive to Pb neurotoxicity. However, these differences cannot be accounted for on the basis of Pb exposure since weight gain and water consumption did not differ between the genders. [Description provided by NIOSH]
• Subjects:
  Animals Immune System Lead Nervous System Occupational Health Safety Toxicology
• Keywords:
  Animal Studies Immune System Nervous System Neurotoxic Effects Neurotoxicity
• ISSN:
  0731-9193
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  10-11
• Volume:
  15
• Issue:
  1
• NIOSHTIC Number:
  nn:20060147
• Citation:
  Toxicologist 1995 Mar; 15(1):10-11
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  1995
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  False
• Start Date:
  19920701
• Source Full Name:
  The Toxicologist. Society of Toxicology 34th Annual Meeting, March 5-9,1995, Baltimore, Maryland
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b858783188570ec0e0bb6ce521f7ec1c5e6ae70a6d575cf1ac65c580f997dff34a223b5ed20191d27873671016f9c48a259f551ce7c98e19c663c012eaff7adc
• Download URL:
  https://stacks.cdc.gov/view/cdc/224150/cdc_224150_DS1.pdf
• File Type:
  [PDF - 259.52 KB ]