Progressive Deficits in Retrograde Axon Transport Precede Degeneration of Motor Axons in Acrylamide Neuropathy

Details

• Personal Author:
  Moretto A ; Sabri MI
• Description:
  Single injection of acrylamide (1.3 mmol/kg, i.p.) inhibited retrograde axon transport of [125I]tetanus toxin in hen sensory and motor axons. Retrograde axon transport deficits appeared within hours of dosing with acrylamide. The inhibitory effect of acrylamide on retrograde axon transport was transient since transport deficits were not detectable 35 h after dosing. Acrylamide impaired the retrograde movement but not the uptake of [125I]tetanus toxin in the axon. Multiple doses of acrylamide (0.42 mmol/kg, i.p.) induced progressive clinical signs of acrylamide neuropathy that correlated with increasing deficits in retrograde axon transport of [125I]tetanus skin to ventral spinal cord. Deficits were also observed in sensory neurons but were not statistically significant. Accumulated decrements in retrograde axon transport may be the underlying cause of degeneration of motor axons in acrylamide neuropathy in fowl. [Description provided by NIOSH]
• Subjects:
  Animals Nervous System Occupational Health Safety
• Keywords:
  Acrylamide Animal Studies Author Keywords: Acrylamide Axonal Transport Axonopathy Neurological System Neuropathy Neurophysiological Effects Neurotoxic Effects Neurotoxicology Neurotoxin Neurotoxins Retrograde Transport Sciatic Nerve Spinal Cord

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• ISSN:
  0006-8993
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  18-24
• Volume:
  440
• Issue:
  1
• NIOSHTIC Number:
  nn:20060128
• Citation:
  Brain Res 1988 Feb; 440(1):18-24
• Contact Point Address:
  M.I. Sabri. Institute of Neurotoxicology, Albert Einstein College of Medicine, Kennedy Center, Room 518, Bronx, NY 10461, U.S.A.
• CAS Registry Number:
  Acrylamide (CAS RN 79-06-1)
• Federal Fiscal Year:
  1988
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19850501
• Source Full Name:
  Brain Research
• End Date:
  19910430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b09b7b3ff93d2286031c0d553051a6981ac0eeca0cdbdd31b5fb2eba0afd9b4166e403a21a920df5eaa02031f1ca466e704b27af068f197ffd0074b558767036
• Download URL:
  https://stacks.cdc.gov/view/cdc/224137/cdc_224137_DS1.pdf
• File Type:
  [PDF - 645.70 KB ]