Distribution of Composite CYP1A1 Genotypes in Africans, African-Americans and Caucasians

Details

• Personal Author:
  Bayo S ; Buxbaum J ; Crofts F ; Garte SJ ; Taioli E ; Toniolo P ; Trachman J
• Description:
  We present the genotype distribution of the CYP1A1 gene in a sample of over 300 subjects of various ethnic origins. Genotypes are presented as composites of eight possible alleles, taking into account the three major polymorphisms, including a recently described African-American-specific MspI RFLP. A new nomenclature system is presented for clarifying the various haplotypes. Interesting interracial differences in allelic frequencies and admixture rates were observed for the three polymorphisms. Because of the importance of the CYP1A1 gene (which encodes the aromatic hydrocarbon hydroxylase) as a biomarker of genetic susceptibility to environmental carcinogens such as polycyclic aromatic hydrocarbons, these data may provide a useful reference for future studies of relationships between CYP1A1 genotype and disease susceptibility. [Description provided by NIOSH]
• Subjects:
  Biomarkers Epidemiology Genetics Occupational Health Race Factors Safety
• Keywords:
  Admixture Author Keywords: Ethnicity Deoxyribonucleic Acids DNA Gene Mutation Genes Genetic Factors Genotype Metabolic Genes PCR Racial Factors RFLP Susceptibility

  More +
• ISSN:
  0001-5652
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  121-127
• Volume:
  46
• Issue:
  3
• NIOSHTIC Number:
  nn:20060028
• Citation:
  Hum Hered 1996 May-Jun; 46(3):121-127
• Contact Point Address:
  Dr. Seymour J. Garte, Department of Environmental Medicine, New York University Medical Center, 550 First Avenue, New York, NY 10016
• Federal Fiscal Year:
  1996
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Human Heredity
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:617b0e754028854a9cf316aa6f0215e3d0af7f21fca8f0f05034598880ce1152e00c608fba5186cede7640f2ad6404464db564b66c4194cda3d4c6ede71d4bda
• Download URL:
  https://stacks.cdc.gov/view/cdc/224065/cdc_224065_DS1.pdf
• File Type:
  [PDF - 963.27 KB ]