A Novel CYP1A1 Gene Polymorphism in African-Americans

Details

• Personal Author:
  Cosma GN ; Crofts F ; Currie D ; Garte SJ ; Taioli E ; Toniolo P
• Description:
  A new Mspl RFLP in the CYP1A1 gene has been found in genomic DNA from African-Americans. The polymorphism results from a single A-T to G-C transition in the 3' noncoding region about 300 bp upstream from the polyadenylation site. This mutation leads to cleavage of the normal 2.3 kb Mspl restriction fragment into 1.3 and 1.0 kb fragments. The heterozygous mutation has been seen in 8 of 47 African-Americans, but was not detected in 191 Caucasians or 30 Asians. No linkage was observed with either of the two previously described polymorphisms in this gene. [Description provided by NIOSH]
• Subjects:
  Genetics Occupational Health Race Factors Safety
• Keywords:
  Deoxyribonucleic Acids DNA Gene Mutation Genes Genetic Factors Racial Factors
• ISSN:
  0143-3334
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  9
• NIOSHTIC Number:
  nn:20060025
• Citation:
  Carcinogenesis 1993 Sep; 14(9):1729-1731
• Contact Point Address:
  Seymour J.Garte, Nelson Institute of Environmental Medicine, New York University Medical Center, New York, NY 10016, USA
• Federal Fiscal Year:
  1993
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Carcinogenesis
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:42b5cd932304a7c492d5be8fe6267707e8cb94e877fd496ae0cf79b9000614062ea357b6de164ffa7b713aa9d141d146a0083672b589b8846d65b98d1aa1c95d
• Download URL:
  https://stacks.cdc.gov/view/cdc/224062/cdc_224062_DS1.pdf
• File Type:
  [PDF - 1.88 MB ]