Racial Differences in CYP1A1 Genotype and Function

Details

• Personal Author:
  Bayo S ; Crofts F ; Garte SJ ; Taioli E ; Toniolo P ; Trachman J ; Bayo S ; Crofts F ; Garte SJ ; Taioli E ; Toniolo P ; Trachman J
• Description:
  The cytochrome P450 1A1 (CYP1A1) gene may be of critical importance in determining individual cancer susceptibility to aromatic hydrocarbons such as those in tobacco smoke. We compared the frequencies of CYP1A1 haplotypes, and complete genotypes, taking into account polymorphisms at 3 sites, including an African-specific polymorphism. No concordance was observed in Africans or African-Americans between any of the 3 polymorphisms, (Mspl restriction fragment length polymorphism (RFLP) -- 'M', exon 7 -- 'E', new RFLP -- 'A') in contrast to the concordance seen between the M and E polymorphisms in Caucasians and Asians. We observed an effect of the E polymorphism on enzyme activity and mRNA induction in Asians and Caucasians. [Description provided by NIOSH]
• Subjects:
  Genetics Neoplasms Occupational Health Race Factors Safety
• Keywords:
  Cancer Rates Deoxyribonucleic Acids DNA Gene Mutation Genes Genetic Factors Genotype Racial Factors
• ISSN:
  0378-4274
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  357-362
• Volume:
  77
• Issue:
  1
• NIOSHTIC Number:
  nn:20060059
• Citation:
  Toxicol Lett 1995 May; 77(1-3):357-362
• Contact Point Address:
  Emanuela Taioli, Department of Environmental Medicine, New York University Medical Center, 241 E. 25 St., New York, NY 10010, USA
• Federal Fiscal Year:
  1995
• Performing Organization:
  Mount Sinai School of Medicine, New York
• Peer Reviewed:
  True
• Start Date:
  19920701
• Source Full Name:
  Toxicology Letters
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:43b2033ebf6977ad6bbd25a40c6104373742cb1c267256a4719804692c894ec028454d92403d0500ca89b7c1742fb99cd13b82edf71f3c5f6cbe145db9135cf6
• Download URL:
  https://stacks.cdc.gov/view/cdc/224092/cdc_224092_DS1.pdf
• File Type:
  [PDF - 523.92 KB ]