Urinary Metabolite Concentrations of Organophosphorous Pesticides, Bisphenol A, and Phthalates Among Pregnant Women in Rotterdam, the Netherlands: The Generation R Study

Details

• Personal Author:
  Angerer J ; Burdorf A ; Duty S ; Hauser R ; Hofman A ; Jaddoe VWV ; Longnecker MP ; Mackenbach JP ; Park MM ; Pierik FH ; Steegers EAP ; Tiemeier H ; Ye X
• Description:
  Concern about potential health impacts of low-level exposures to organophosphorus (OP) pesticides, bisphenol A (BPA), and phthalates among the general population is increasing. We measured levels of six dialkyl phosphate (DAP) metabolites of OP pesticides, a chlorpyrifos-specific metabolite (3,5,6-trichloro-2-pyridinol, TCPy), BPA, and 14 phthalate metabolites in urine samples of 100 pregnant women from the Generation R study, the Netherlands. The unadjusted and creatinine-adjusted concentrations were reported, and compared to National Health and Nutrition Examination Survey and other studies. In general, these metabolites were detectable in the urine of the women from the Generation R study and compared with other groups, they had relatively high-level exposures to OP pesticides and several phthalates but similar exposure to BPA. The median concentrations of total dimethyl (DM) metabolites was 264.0 n mol/g creatinine (Cr) and of total DAP was 316.0 n mol/g Cr. The median concentration of mono-ethyl phthalate (MEP) was 222.0 microg/g Cr; the median concentrations of mono-isobutyl phthalate (MiBP) and mono-n-butyl phthalate (MnBP) were above 50 microg/g Cr. The median concentrations of the three secondary metabolites of di-2-ethylhexyl phthalate (DEHP) were greater than 20 microg/g Cr. The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Environmental Exposure Insecticides Occupational Health Organophosphates Phthalic Acids Pregnancy Safety Urine Women
• Keywords:
  Author Keywords: Organophosphorus Pesticides Biological Monitoring Bisphenol A BPA Environmental Exposure Metabolites Organonitrogen Pesticides Organophosphorus Compounds Phthalates Prenatal Exposure
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  260-267
• Volume:
  108
• Issue:
  2
• NIOSHTIC Number:
  nn:20059959
• Citation:
  Environ Res 2008 Oct; 108(2):260-267
• Contact Point Address:
  Matthew P. Longnecker, Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), MD A3-05, PO Box 12233, Research Triangle Park, NC 27709
• Email:
  longnec1@niehs.nih.gov
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7) ; 3,5,6-Trichloro-2-pyridinol (CAS RN 6515-38-4) ; Dioctyl phthalate (CAS RN 117-81-7) ; Monoethyl phthalate (CAS RN 2306-33-4) ; Monoisobutyl phthalate (CAS RN 30833-53-5)
• Federal Fiscal Year:
  2009
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:608de9a1a1746931bd049e3bafea3c9a2bc87059bb7cea33947686a960ef6e3d05da2360c6709cb15784823ddf3a329389557fffbe5df8eb1505e44281b70e88
• Download URL:
  https://stacks.cdc.gov/view/cdc/224009/cdc_224009_DS1.pdf
• File Type:
  [PDF - 322.75 KB ]