Exposure to Bisphenol A and Phthalates Metabolites in the Third Trimester of Pregnancy and BMI Trajectories

Details

• Personal Author:
  Cantoral A ; Meeker JD ; Peterson KE ; Sánchez BN ; Solano M ; Tellez-Rojo MM ; Yang TC ; Zhang Z
• Description:
  Background: Bisphenol A (BPA) and phthalates metabolites are linked to a variety of adverse health consequences but studies have not explored their association with growth trajectories. Objective: Explore body mass index (BMI) trajectories for tertile exposures to BPA and phthalates metabolites in the third trimester of pregnancy. Methods: We constructed BMI (kg/m2) trajectories from birth to 14 years in a birth cohort of 249 children from Mexico City using tertiles of third trimester maternal urinary concentrations of BPA and phthalates metabolites. Fractional age polynomials and mixed effects models were fit separately by sex. Predicted models were plotted for each metabolite tertile with the covariates mother's education and BMI centered at average values. Results: Highest predicted BMI trajectories for female children were observed for third tertile exposure to the phthalate metabolite mono(2-ethyl-5-carboxypentyl) phthalate. In male children, first tertile exposure to mono-isobutyl phthalate and monobenzyl phthalate and second tertile exposure to mono(2-ethylhexyl) phthalate and mono(2-ethyl-5-hydroxyhexyl) phthalate predicted the highest BMI trajectory by adolescence. There was no relationshsip between BPA and child growth trajectory. Conclusions: These results suggest sex-specific differences in BMI trajectories by levels of metabolite exposure. Additional studies are needed to consider growth through adolescence in assessing the association of pregnancy exposures on child's BMI. [Description provided by NIOSH]
• Subjects:
  Adolescent Demography Energy Metabolism Environmental Exposure Epidemiology Occupational Health Phenol Phthalic Acids Pregnancy Safety Urine Women

  More +
• Keywords:
  Adolescents Author Keywords: BMI Bisphenol A BMI Body Mass Index BPA Children Demographic Characteristics Environmental Exposure Exposure Levels Growth Trajectory Humans Metabolites Models Phenols Phthalates Urine Chemistry

  More +
• ISSN:
  2047-6310
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  9
• NIOSHTIC Number:
  nn:20055319
• Citation:
  Pediatr Obes 2018 Sep; 13(9):550-557
• Contact Point Address:
  KE Peterson, Department of Nutritional Sciences, University of Michigan School of Public Health, 1867 SPH I, 1415 Washington Heights, Ann Arbor MI 48109
• Email:
  karenep@umich.edu
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Pediatric Obesity
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:89e58b1637762d81ab0e80c43d7299a0b8c4d73c5f01cf62e56b6eb0562b2ba30cfad3ffcedfbadd2cf408cc6a46c029ae2ce4899f36ceff3f686556c9ff921c
• Download URL:
  https://stacks.cdc.gov/view/cdc/217655/cdc_217655_DS1.pdf
• File Type:
  [PDF - 278.36 KB ]