Longitudinal Trends in Renal Function Among First Time Sugarcane Harvesters in Guatemala

Details

• Personal Author:
  Asensio C ; Asturias EJ ; Butler-Dawson J ; Cruz A ; Dally M ; Johnson RJ ; Krisher L ; Newman, Lee S. ; Pilloni WD
• Description:
  Introduction: Chronic kidney disease of unknown origin (CKDu) is an epidemic concentrated in agricultural communities in Central and South America, including young, male sugarcane harvesters. The purpose of this analysis is to understand early changes in kidney function among a cohort of first-time sugarcane harvesters and to determine risk factors for kidney function decline. Methods: Joint latent class mixed models were used to model sub-population kidney function trajectory over the course of 4 years (2012-2016). Probability weighted logistic regression was used to determine personal health, community, and individual behavior risk factors associated with sub-population assignment. Data analysis occurred in 2019. Results: Of 181 new workers median age 19 years old (IQR: 4), 39 (22%) were identified as having non-stable kidney function with an annual age-adjusted decline of estimated glomerular filtration rate (eGFR) of -1.0 ml/min per 1.73 m2 (95% CI: -3.4, 1.3). Kidney function (OR: 0.96; 95% CI: 0.93, 0.98), mild hypertension (OR: 5.21; 95% CI: 2.14, 13.94), and having a local home of residence (OR: 7.12; 95% CI: 2.41, 26.02) prior to employment in sugarcane were associated with non-stable eGFR sub-population assignment. Conclusions: Mild hypertension may be an early indicator of the development of CKDu. A better understanding of preexisting risk factors is needed to determine why individuals are entering the workforce with reduced kidney function and elevated blood pressure and increased risk of renal function decline. [Description provided by NIOSH]
• Subjects:
  Agriculture Occupational Health Safety
• Keywords:
  Agricultural Workers Kidney Disorders Kidney Function Longitudinal Study Outdoor Workers
• ISSN:
  1932-6203
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  3
• NIOSHTIC Number:
  nn:20059885
• Citation:
  PLoS One 2020 Mar; 15(3):e0229413
• Email:
  miranda.dally@cuanschutz.edu
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Manufacturing ; Services
• Performing Organization:
  University of Colorado Denver, Aurora
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  PLoS One
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7fb0d94d58f9ed07482329ca3248959a210beebcb1078df1a980f79cee9ebb3b91699927f76a302ede3264930ca46877cbfac52f1ab39639bc87ce7d0b2465ea
• Download URL:
  https://stacks.cdc.gov/view/cdc/223941/cdc_223941_DS1.pdf
• File Type:
  [PDF - 713.04 KB ]