Association of Copeptin, a Surrogate Marker of Arginine Vasopressin, with Decreased Kidney Function in Sugarcane Workers in Guatemala

Details

• Personal Author:
  Brindley S ; Butler-Dawson J ; Dally M ; Griffin BR ; Johnson EC ; Johnson RJ ; Krisher L ; Newman, Lee S. ; Sánchez-Lozada L-G
• Description:
  Background: Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. Methods: Utilizing a longitudinal study of 105 workers in Guatemala, we examined relationships between hydration indices, plasma copeptin concentrations, and kidney function markers at 3 times during the 6-month harvest. We also examined whether baseline copeptin concentrations increased the odds of developing an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Results: Copeptin concentrations were positively associated with serum creatinine (ß 1.41, 95% CI 0.88-2.03) and negatively associated with eGFR (ß -1.07, 95% CI -1.43 to -0.70). In addition, as workers improved their hydration (measured by increases in fluid balance), copeptin concentrations were reduced, and this reduction was associated with an improvement in kidney function. Conclusions: Results suggest that copeptin should be studied as a potential prognostic biomarker. [Description provided by NIOSH]
• Subjects:
  Agriculture Biomarkers Hot Temperature Occupational Health Safety
• Keywords:
  Agricultural Workers Author Keywords: Vasopressin Heat Exposure Hydration Kidney Kidney Disorders Kidney Function Outdoor Workers
• ISSN:
  0250-6807
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8 ; Wyoming
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  30-36
• Volume:
  76
• Issue:
  1
• NIOSHTIC Number:
  nn:20059875
• Citation:
  Ann Nutr Metab 2020 May; 76(1):30-36
• Contact Point Address:
  Jaime Butler-Dawson, Center for Health, Work, and Environment, Colorado School of Public Health, 13001 E. 17th Pl., Ste. W3111, Aurora, CO 80045
• Email:
  Jaime.butler-dawson@cuanschutz.edu
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Manufacturing ; Services
• Performing Organization:
  University of Colorado Denver, Aurora
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Annals of Nutrition & Metabolism
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:524a4fdc176bef563c6c7d21417d031b1d9e962eaf95bbec094f1e33769791063f7975b058e0e9e6dd9ed5c1db49e57f1d031964c366fbaa885e9ca4cadafec8
• Download URL:
  https://stacks.cdc.gov/view/cdc/223932/cdc_223932_DS1.pdf
• File Type:
  [PDF - 156.13 KB ]