Sugarcane workweek study: mechanisms underlying daily changes in creatinine.

Details

• Personal Author:
  Asensio C ; Butler-Dawson J ; Dally M ; Griffin BR ; Jaramillo D ; Johnson RJ ; Krisher L ; Newman L ; Sorensen CJ
• Description:
  Chronic kidney disease of unknown origin (CKDu) is an epidemic that has resulted in tens of thousands of deaths among workers in Latin America. It has been hypothesized that work, especially among sugarcane harvesters, contributes to the progression of disease through recurrent clinical and subclinical acute kidney injury. In a previous study, we observed that among the same cohort of Guatemalan sugarcane harvesters, subgroups experienced differing degrees of daily changes in creatinine. Workers with the largest daily fluctuations experienced the greatest decline in renal function by the end of the harvest season. In this study, we present and assess the plausibility of 3 hypotheses as to why these workers experienced severe daily changes in creatinine across the workshift: (i) intense work performed in hot environments with inadequate hydration leads to volume depletion and pre-renal kidney injury; (ii) muscle breakdown throughout the course of the workday leads to transient artificial spikes in serum creatinine and/or causes direct renal injury; and (iii) workers have pre-existing subclinical renal dysfunction that is exacerbated by either volume depletion, muscle breakdown, or a combination of these conditions. Methods to address these questions are provided in the Supplementary Methods. [Description provided by NIOSH]
• Subjects:
  Agriculture Cohort Studies Hot Temperature Occupational Health Safety
• Keywords:
  Kidney disorders; Kidney function; Outdoor workers; Agricultural workers; Agriculture; Cohort studies; Hot environments
• ISSN:
  2468-0249
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Iowa ; OSHA Region 7 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  6
• Issue:
  12
• NIOSHTIC Number:
  nn:20065526
• Citation:
  Kidney Int Rep 2021 Dec; 6(12):3083-3086
• Contact Point Address:
  Miranda Dally, Center for Health, Work & Environment, Colorado School of Public Health, CU Anschutz Medical Campus, 13001 E. 17th Place, Aurora, Colorado 80045, USA
• Email:
  miranda.dally@cuanschutz.edu
• CAS Registry Number:
  Creatinine (CAS RN 60-27-5)
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of Colorado Denver, Aurora
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Kidney International Reports
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1e3feddff1247f28ff803a7ad566cdf183a661d29b7715c0f1e29ad11130a4792be2e6533586fed8dec6088e290d35b95d903855f23e4005d8c443b603449178
• Download URL:
  https://stacks.cdc.gov/view/cdc/249463/cdc_249463_DS1.pdf
• File Type:
  [PDF - 727.56 KB ]