Magnetic Resonance Spectroscopy and Environmental Toxicant Exposure

Details

• Personal Author:
  Weisskopf MG
• Description:
  The study of neurological impacts of toxicants has emphasized neuropsychological tests as important outcome variables. Direct assessment of neural substrates of environmental impacts could offer many advantages. I discuss our use of magnetic resonance spectroscopy (MRS) in the neurological assessment of adult lead poisoning of monozygotic twins as an example. Cognitive testing showed frontal lobe dysfunction in both twins, and more dramatic hippocampal dysfunction in the twin with higher lead exposure (JG). MRS showed lower N-acetylaspartate/creatine ratios in JG. The findings illustrate the potential utility of MRS in assessing impacts of not only lead, but other toxicants as well. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Environmental Exposure Hazardous Substances Lead Lead Poisoning Men Mental Health Nervous System Nervous System Diseases Occupational Health Pathology Poisoning Safety Women

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• Keywords:
  Children Cognitive Function Environmental Exposure Health Effects Humans Lead Poisoning Metabolism Neurological Disorders Neurological System Neurotoxic Effects Physiological Effects Psychological Effects Toxic Effects Toxins

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• ISSN:
  0077-8923
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  179-182
• Volume:
  1097
• NIOSHTIC Number:
  nn:20059830
• Citation:
  Ann NY Acad Sci 2007 Feb; 1097:179-182
• Contact Point Address:
  Marc G Weisskopf, Department of Environmental Health, Harvard School of Public Health, Occupational Health Program, Landmark Center, 401 Park Dr., P.O. Box 15697, Boston, MA 02215
• Email:
  mweissko@hsph.harvard.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of the New York Academy of Sciences
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6eba226bd2181435b855c26fe0577a31ab0f487951ed9a219df12b01917acbe37d61808af6a4007218ccc8e485776bc126510a1f058efc8b3e3a261e38561e64
• Download URL:
  https://stacks.cdc.gov/view/cdc/223898/cdc_223898_DS1.pdf
• File Type:
  [PDF - 32.27 KB ]