Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead

Details

• Personal Author:
  Hu H ; Schwartz BS ; Shih RA ; Weisskopf MG
• Description:
  OBJECTIVE: We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults. DATA SOURCES: A systematic search of electronic databases resulted in 21 environmental and occupational studies from 1996 to 2006 that examined and compared associations of recent (in blood) and cumulative (in bone) lead doses with neurobehavioral outcomes. DATA EXTRACTION: Data were abstracted after consideration of exclusion criteria and quality assessment, and then compiled into summary tables. CONCLUSIONS: At exposure levels encountered after environmental exposure, associations with bio-markers of cumulative dose (mainly lead in tibia) were stronger and more consistent than associations with blood lead levels. Similarly, in studies of former workers with past occupational lead exposure, associations were also stronger and more consistent with cumulative dose than with recent dose (in blood). In contrast, studies of currently exposed workers generally found associations that were more apparent with blood lead levels; we speculate that the acute effects of high, recent dose may mask the chronic effects of cumulative dose. There is moderate evidence for an association between psychiatric symptoms and lead dose but only at high levels of current occupational lead exposure or with cumulative dose in environmentally exposed adults. [Description provided by NIOSH]
• Subjects:
  Blood Environmental Exposure Hematologic Tests Lead Lead Poisoning Men Occupational Exposure Occupational Health Safety Women
• Keywords:
  Author Keywords: Adults Blood Blood-samples Bone Cognitive Function Environmental-exposure Humans Lead Lead-absorption Lead-poisoning Neurobehavior Occupational-exposure

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Massachusetts ; OSHA Region 1 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  483-492
• Volume:
  115
• Issue:
  3
• NIOSHTIC Number:
  nn:20037719
• Citation:
  Environ Health Perspect 2007 Mar; 115(3):483-492
• Contact Point Address:
  B.S. Schwartz, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St., Rm. W7041, Baltimore, Maryland 21205 USA
• Email:
  bschwart@jhsph.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:936a327384b56e7b302b3263fda6ea8aeff51d633a5840ac1b556e25787912ece2463fed38cffa27581f5073965d3b9555963cbaa80e0aa9efb2af266540b40b
• Download URL:
  https://stacks.cdc.gov/view/cdc/191709/cdc_191709_DS1.pdf
• File Type:
  [PDF - 521.24 KB ]