Environmental lead exposure and cognitive function in community-dwelling older adults

Details

• Personal Author:
  Bandeen-Roche K ; Bolla KI ; Carlson MC ; Glass TA ; Schwartz BS ; Shih RA ; Todd AC
• Description:
  OBJECTIVE: To determine if long-term exposure to high levels of lead in the environment is associated with decrements in cognitive ability in older Americans. METHODS: We completed a cross-sectional analysis using multiple linear regression to evaluate associations of recent (in blood) and cumulative (in tibia) lead dose with cognitive function in 991 sociodemographically diverse, community-dwelling adults, aged 50 to 70 years, randomly selected from 65 contiguous neighborhoods in Baltimore, MD. Tibia lead was measured with (109)Cd induced K-shell X-ray fluorescence. Seven summary measures of cognitive function were created based on standard tests in these domains: language, processing speed, eye-hand coordination, executive functioning, verbal memory and learning, visual memory, and visuoconstruction. RESULTS: The mean (SD) blood lead level was 3.5 (2.2) microg/dL and tibia lead level was 18.7 (11.2) microg/g. Higher tibia lead levels were consistently associated with worse cognitive function in all seven domains after adjusting for age, sex, APOE-epsilon4, and testing technician (six domains p
• Subjects:
  Aging Blood Demography Environmental Exposure Epidemiology Hematologic Tests Lead Lead Poisoning Men Nervous System Occupational Health Safety Women

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• Keywords:
  Age-groups Analytical-methods Blood-analysis Blood-samples Demographic-characteristics Environmental-exposure Exposure-levels Humans Lead-absorption Lead-poisoning Nervous-system Neurological-system Statistical-analysis

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• ISSN:
  0028-3878
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; New York ; OSHA Region 2 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  67
• Issue:
  9
• NIOSHTIC Number:
  nn:20037676
• Citation:
  Neurology 2006 Nov; 67(9):1556-1562
• Contact Point Address:
  Dr. Brian S. Schwartz, Division of Occupational and Environmental Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room W7041, Baltimore, MD 21205
• Email:
  bschwart@jhsph.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Neurology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d3ed7a42841f51b10bfc24f560715ae37664acfcc81428bacadf8e1e5e75aa736bab02acccc573f623d1fd6d56befbdffa52b81805024a146156c9e31dc9b037
• Download URL:
  https://stacks.cdc.gov/view/cdc/191673/cdc_191673_DS1.pdf
• File Type:
  [PDF - 365.29 KB ]